I'm set to start it as soon as it hits my door from the Foundation pharmacy. There have been studies published that within as little as two weeks PFT's have increased as much as 15%. In more than a few cases some test subjects have gained as much as twenty to thirty pounds. @amber682 and @rubyroselee, Vertex is saying if you have the G551D mutation then you'll get it. Foundation Care is selling it at cost and I'm sure most insurance companies would much rather pick up that tab than check out on two or three hospital stays a year. As far as VX-809 is concerned I was unable to find anything that said whether or not the results are expected to be the same. Considering that they are alike in theory, not function, that is to treat the root of the problem, we can only hope that the results will be very much alike. It'll be interesting to see what happens when the two are paired to treat those like @jessykt with the heterozygous DF508 and G551D mutations. @MiahsMommy, because the drug's still in its infant stages, I've gathered, it isn't known what maintenance meds we'll still have to continue doing. More than likely we will stay the same course we're on. Hopefully, TOBI will find it's way out of our typical day, due to fewer exacerbations and infections. It's important to remind ourselves that although it's the closest thing to a cure, it isn't. But it is certainly the best time in the history of this disease to be ailed by it. My family and many others have been robbed of precious lives. I feel blessed but ultimately undeserving that I'm one of the few 4% that will be receiving it. I wish your families well.