OK science people

EnergyGal

New member
Thank you Rami. GREAT explantation.

If I were Wanderlost, I would be doing extra therapies to see if I could knock down the strain myself. I have in the past and after two weeks of intensive extra therapy, I cleared up my lungs.
 

wanderlost

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Risa</b></i>

Thank you Rami. GREAT explantation.



If I were Wanderlost, I would be doing extra therapies to see if I could knock down the strain myself. I have in the past and after two weeks of intensive extra therapy, I cleared up my lungs.</end quote></div>

tell me what you did??



Ihatecf - (I hate Cf too!) - thank you for your explanation.

It sounds like from the above posts that a few things could happen - 1) I may culture PA later and not be resistant, 2) I may still be able to use Tobi and it will work - and/or I may be able to take it in conjunction with something else....sound right??
 

wanderlost

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Risa</b></i>

Thank you Rami. GREAT explantation.



If I were Wanderlost, I would be doing extra therapies to see if I could knock down the strain myself. I have in the past and after two weeks of intensive extra therapy, I cleared up my lungs.</end quote></div>

tell me what you did??



Ihatecf - (I hate Cf too!) - thank you for your explanation.

It sounds like from the above posts that a few things could happen - 1) I may culture PA later and not be resistant, 2) I may still be able to use Tobi and it will work - and/or I may be able to take it in conjunction with something else....sound right??
 

wanderlost

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Risa</b></i>

Thank you Rami. GREAT explantation.



If I were Wanderlost, I would be doing extra therapies to see if I could knock down the strain myself. I have in the past and after two weeks of intensive extra therapy, I cleared up my lungs.</end quote></div>

tell me what you did??



Ihatecf - (I hate Cf too!) - thank you for your explanation.

It sounds like from the above posts that a few things could happen - 1) I may culture PA later and not be resistant, 2) I may still be able to use Tobi and it will work - and/or I may be able to take it in conjunction with something else....sound right??
 

EnergyGal

New member
In the past, I would have Chest PT Twice daily. When I needed a clean out, I would have four Chest PT daily. I would call in a therapist and they would do the therapy just like in the hospital. After two weeks, my chest would sound very clear.

I wish you the best. Maybe you can try extra therapies to see if it works and after five days, you still feel you need the medications take them.
 

EnergyGal

New member
In the past, I would have Chest PT Twice daily. When I needed a clean out, I would have four Chest PT daily. I would call in a therapist and they would do the therapy just like in the hospital. After two weeks, my chest would sound very clear.

I wish you the best. Maybe you can try extra therapies to see if it works and after five days, you still feel you need the medications take them.
 

EnergyGal

New member
In the past, I would have Chest PT Twice daily. When I needed a clean out, I would have four Chest PT daily. I would call in a therapist and they would do the therapy just like in the hospital. After two weeks, my chest would sound very clear.

I wish you the best. Maybe you can try extra therapies to see if it works and after five days, you still feel you need the medications take them.
 

Ratatosk

Administrator
Staff member
Can you not only increase the number of treatments, but increase the amount of time and the pressure? Think Amy posted in her Warwick blog about using as much pressure as one can handle.
 

Ratatosk

Administrator
Staff member
Can you not only increase the number of treatments, but increase the amount of time and the pressure? Think Amy posted in her Warwick blog about using as much pressure as one can handle.
 

Ratatosk

Administrator
Staff member
Can you not only increase the number of treatments, but increase the amount of time and the pressure? Think Amy posted in her Warwick blog about using as much pressure as one can handle.
 

NoExcuses

New member
i haven't read through any of the posts so if this is a repeat forgive me.

Ever heard of people picking up MRSA? That's Staph that's resistant to Methicillin. Even if they've never been on a emthicillin antibiotic, they're resistant to it.

Same goes with PA.

You can pick up a strain of PA that's already resistant to a class of antibiotics just as easily as you can pick up a strain that suseptible to antibiotics.

You could have picked up a strain of PA that's resistant to quinlonoes (instead of the strain that you have that's resistant to aminoglycosides).

Just the way it is.......
 

NoExcuses

New member
i haven't read through any of the posts so if this is a repeat forgive me.

Ever heard of people picking up MRSA? That's Staph that's resistant to Methicillin. Even if they've never been on a emthicillin antibiotic, they're resistant to it.

Same goes with PA.

You can pick up a strain of PA that's already resistant to a class of antibiotics just as easily as you can pick up a strain that suseptible to antibiotics.

You could have picked up a strain of PA that's resistant to quinlonoes (instead of the strain that you have that's resistant to aminoglycosides).

Just the way it is.......
 

NoExcuses

New member
i haven't read through any of the posts so if this is a repeat forgive me.

Ever heard of people picking up MRSA? That's Staph that's resistant to Methicillin. Even if they've never been on a emthicillin antibiotic, they're resistant to it.

Same goes with PA.

You can pick up a strain of PA that's already resistant to a class of antibiotics just as easily as you can pick up a strain that suseptible to antibiotics.

You could have picked up a strain of PA that's resistant to quinlonoes (instead of the strain that you have that's resistant to aminoglycosides).

Just the way it is.......
 

NoExcuses

New member
Here's another twist.

When they do breakpoint testing (which is what it's caled when they test suspeptibility), it's for IV concentrations.

TOBI, unlike tobramycin, can reach much higher concentrations in your lungs. Because it's not systemically available, and it goes direclty to the site of the infection, TOBI can be placed in the lungs at much higher concentrations than IV's.

So IV tobra might not work, but TOBI may. If TOBI can get to the site of the infection. Sometimes it can't because mucus is blocking the way.

Combo therapy for resistance is an option. 1 antibiotic + 1 other antibiotic = strength of 3 antibiotics, my doc explains to me. synergy testing can be done, so you're not SOL if you're aminoglycoside resistant.
 

NoExcuses

New member
Here's another twist.

When they do breakpoint testing (which is what it's caled when they test suspeptibility), it's for IV concentrations.

TOBI, unlike tobramycin, can reach much higher concentrations in your lungs. Because it's not systemically available, and it goes direclty to the site of the infection, TOBI can be placed in the lungs at much higher concentrations than IV's.

So IV tobra might not work, but TOBI may. If TOBI can get to the site of the infection. Sometimes it can't because mucus is blocking the way.

Combo therapy for resistance is an option. 1 antibiotic + 1 other antibiotic = strength of 3 antibiotics, my doc explains to me. synergy testing can be done, so you're not SOL if you're aminoglycoside resistant.
 

NoExcuses

New member
Here's another twist.

When they do breakpoint testing (which is what it's caled when they test suspeptibility), it's for IV concentrations.

TOBI, unlike tobramycin, can reach much higher concentrations in your lungs. Because it's not systemically available, and it goes direclty to the site of the infection, TOBI can be placed in the lungs at much higher concentrations than IV's.

So IV tobra might not work, but TOBI may. If TOBI can get to the site of the infection. Sometimes it can't because mucus is blocking the way.

Combo therapy for resistance is an option. 1 antibiotic + 1 other antibiotic = strength of 3 antibiotics, my doc explains to me. synergy testing can be done, so you're not SOL if you're aminoglycoside resistant.
 

Alessia2dance

New member
That' what happened toe me. When I got the results from my culture back it said that I was resistant to tobramycin. When I asked them to explain because I currently take TOBI, They said I was resistant to the IV form but not the aerosol.
 

Alessia2dance

New member
That' what happened toe me. When I got the results from my culture back it said that I was resistant to tobramycin. When I asked them to explain because I currently take TOBI, They said I was resistant to the IV form but not the aerosol.
 

Alessia2dance

New member
That' what happened toe me. When I got the results from my culture back it said that I was resistant to tobramycin. When I asked them to explain because I currently take TOBI, They said I was resistant to the IV form but not the aerosol.
 
I

IG

Guest
Probably not applicable but..
Even if you weren't resistant to tobi they probably wouldn't put you on it anyway since you are breastfeeding and tobi has been known to cause hearing loss.

"PREGNANCY and BREAST-FEEDING: Tobi Solution has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tobi Solution while you are pregnant. It is not known if Tobi Solution is found in breast milk after inhalation. Do not breast-feed while taking Tobi Solution." <a target=_blank class=ftalternatingbarlinklarge href="http://www.drugs.com/cdi/tobi_solution.html">http://www.drugs.com/cdi/tobi_solution.html</a>
 
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