when u say twinge, does it feel like hot needles sticking into your bone? if so, then yes, I have that happen from time to time. It can be from a number of things. I noticed it was worse when I had osteoporosis, before my treatment with Forteo. I noticed that it did get better once I was improving and was upgraded to osteopenia. It can also be from arthritis or something else. Mine comes from a number of things. The biggest is fibromyalgia, mild carpal tunnel and arthritis (when I fractured a bone). Mine seems to be at its worse when the weather has a major change like temps, cold front, or pressure change due to storms.