My son had his first hospitalization in Feb and they placed a PICC upon admission. He is 12 yrs old and he didn't have any issues with the placement. The team was great and the PICC was the best choice - easy to access, no soreness (except for the first day) and allowed us to leave after a week to finish with home IVs. The home IVs were really easy. They gave us infusion balls so he could move around with no issues and there is no machine to mess with. The PICC removal was painless for him. The only complication we had was his body produced some scar tissue around the PICC line and it started to come out the night of the PICC removal. Needless to say, a string of tissue coming out of the PICC line hole sent us to ER. The ER doc was perplexed but wasn't concerned. He pulled it out and sent us on our way. We contacted the CF clinic the next day and they said this happens sometimes.