Hi... I've done Home IVs many times and have had a couple of PICC lines. I've only had them clog in the hospital, most of the time because they claim that the type I get (automatic valve- it has a valve inside and doesn't need a clamp on the outside) doesn't need to be flushed with heparin, but I insist because of experience. Also, when my home IV nurse draws blood from the line, she flushes it afterwards with AT LEAST 3 saline syringes... very important. Another thing for PICC care-- they say you can shower if you wrap it up, but my nurse actually said that it's best to just not risk it and take baths/have someone wash your hair over a sink. Even if you're careful, it will still get a little damp and can become painful or infected or messed up. I wouldn't call your experience "normal" but that nurse not flushing out the line probably did do some damage that often does lead to clogging. As for working and doing IVs, my family feels for you-- my mom works full time an hour+ away, and definitely cannot take off the whole time (3 weeks, usually). For the first few times I did Home IVs, she worked a few towns over and just came home and dashed back. But she started working in the Metro area again. By this point I had done Home IVs so many times I was confident I could handle it on my own-- if I could reach the line itself. So my nurse put an attachment on and I do the midday infusion myself-- its really easy once you get the hang of it (as I'm sure you'll soon see). But obviously, it takes a couple of go-rounds to be comfortable enough to do this. For now- you say you're doing 3x/cephapime 2x/tobramycin... which equals 5 times a day (I'm only guessing since they need to be evenly spaced, in my case at least). Maybe your doctor could divide the Tobramycin into 3 separate doses, so it would only be 3 times a day, which is at least a bit easier. I'm not sure if a doctor could even do that, I'm just throwing out ideas since I know what a pain it is to have to be home to do a dose... Good luckWOW this is a very long post lol