Melissa,
Hi! Well, that is great news that you daughter is having her first hospitalization since diagnosis! How old is she?
First of all, no, she will not be able to swim. When she takes a shower/bath, you will need to wrap her arm over the picc to make sure no water gets in. When we are in the hospital, we ask for some extra of the orange and clear Biohazard bags, you cut the closed end off, slip their arm in, then tape around the openings.
As far as playing, yes, they can play, but you do have to be careful of it 'accidently' getting pulled out. We cut off the end of a really soft sock and slip that over Zoe's arm to cover the entire picc area, that really helps a lot.
Good luck with her tune-up!