They may be referring to the 5T, 7T or 9T polymorphism's that people have on the gene that can cause cf. From what I understand everyone has either a 5T, 7T or 9T and the 7T is the normal one to have and does not cause disease. The 5T or 9T can act like a mutation if there are enough of them. Steve from Ambry answred a thread about them a few months ago and I will attempt to post a link to it http://forums.cysticfibrosis.com/messageview.cfm?catid=6&threadid=30665&highlight_key=y.Ok, so my great computer skills aren't working - you can find it by either cutting and pasting that link or by doing a search for a thread that was posted by AbbysMama and it is the first one that comes up - called Needs Some Tutoring - it discussed 5T vs 7T etc.
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Polymorphism
- Thread starter combo76
- Start date
They may be referring to the 5T, 7T or 9T polymorphism's that people have on the gene that can cause cf. From what I understand everyone has either a 5T, 7T or 9T and the 7T is the normal one to have and does not cause disease. The 5T or 9T can act like a mutation if there are enough of them. Steve from Ambry answred a thread about them a few months ago and I will attempt to post a link to it http://forums.cysticfibrosis.com/messageview.cfm?catid=6&threadid=30665&highlight_key=y.Ok, so my great computer skills aren't working - you can find it by either cutting and pasting that link or by doing a search for a thread that was posted by AbbysMama and it is the first one that comes up - called Needs Some Tutoring - it discussed 5T vs 7T etc.
They may be referring to the 5T, 7T or 9T polymorphism's that people have on the gene that can cause cf. From what I understand everyone has either a 5T, 7T or 9T and the 7T is the normal one to have and does not cause disease. The 5T or 9T can act like a mutation if there are enough of them. Steve from Ambry answred a thread about them a few months ago and I will attempt to post a link to it http://forums.cysticfibrosis.com/messageview.cfm?catid=6&threadid=30665&highlight_key=y.Ok, so my great computer skills aren't working - you can find it by either cutting and pasting that link or by doing a search for a thread that was posted by AbbysMama and it is the first one that comes up - called Needs Some Tutoring - it discussed 5T vs 7T etc.
They may be referring to the 5T, 7T or 9T polymorphism's that people have on the gene that can cause cf. From what I understand everyone has either a 5T, 7T or 9T and the 7T is the normal one to have and does not cause disease. The 5T or 9T can act like a mutation if there are enough of them. Steve from Ambry answred a thread about them a few months ago and I will attempt to post a link to it http://forums.cysticfibrosis.com/messageview.cfm?catid=6&threadid=30665&highlight_key=y.Ok, so my great computer skills aren't working - you can find it by either cutting and pasting that link or by doing a search for a thread that was posted by AbbysMama and it is the first one that comes up - called Needs Some Tutoring - it discussed 5T vs 7T etc.
<p>They may be referring to the 5T, 7T or 9T polymorphism's that people have on the gene that can cause cf. From what I understand everyone has either a 5T, 7T or 9T and the 7T is the normal one to have and does not cause disease. The 5T or 9T can act like a mutation if there are enough of them. Steve from Ambry answred a thread about them a few months ago and I will attempt to post a link to it http://forums.cysticfibrosis.com/messageview.cfm?catid=6&threadid=30665&highlight_key=y.<p>Ok, so my great computer skills aren't working - you can find it by either cutting and pasting that link or by doing a search for a thread that was posted by AbbysMama and it is the first one that comes up - called Needs Some Tutoring - it discussed 5T vs 7T etc.
Thank you so much for your replys. Like I said, I had my daughter tested genetically. I was told by the drs. nurse that we can rule out CF - however they found a couple polymorphisms through the genetic testing. When I asked what polymorphisms were, he said he had no idea, and is very confused. Honestly, I don't think they are educated in CF, and neither am I.
Thank you so much for your replys. Like I said, I had my daughter tested genetically. I was told by the drs. nurse that we can rule out CF - however they found a couple polymorphisms through the genetic testing. When I asked what polymorphisms were, he said he had no idea, and is very confused. Honestly, I don't think they are educated in CF, and neither am I.
Thank you so much for your replys. Like I said, I had my daughter tested genetically. I was told by the drs. nurse that we can rule out CF - however they found a couple polymorphisms through the genetic testing. When I asked what polymorphisms were, he said he had no idea, and is very confused. Honestly, I don't think they are educated in CF, and neither am I.
Thank you so much for your replys. Like I said, I had my daughter tested genetically. I was told by the drs. nurse that we can rule out CF - however they found a couple polymorphisms through the genetic testing. When I asked what polymorphisms were, he said he had no idea, and is very confused. Honestly, I don't think they are educated in CF, and neither am I.
Thank you so much for your replys. Like I said, I had my daughter tested genetically. I was told by the drs. nurse that we can rule out CF - however they found a couple polymorphisms through the genetic testing. When I asked what polymorphisms were, he said he had no idea, and is very confused. Honestly, I don't think they are educated in CF, and neither am I.
<br />
<br />
Daddy2Noah
New member
When my son was diagnosed at 8 days old (back in 2006) we spent a week at CHoP for testing, etc...
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
Daddy2Noah
New member
When my son was diagnosed at 8 days old (back in 2006) we spent a week at CHoP for testing, etc...
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
Daddy2Noah
New member
When my son was diagnosed at 8 days old (back in 2006) we spent a week at CHoP for testing, etc...
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
Daddy2Noah
New member
When my son was diagnosed at 8 days old (back in 2006) we spent a week at CHoP for testing, etc...
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
While there, they explained CF in great detail to us, including the symptoms.
Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
Daddy2Noah
New member
When my son was diagnosed at 8 days old (back in 2006) we spent a week at CHoP for testing, etc...
<br />While there, they explained CF in great detail to us, including the symptoms.
<br />
<br />Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
<br />
<br />They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
<br />
<br />Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
<br />
<br />Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
<br />
<br />While there, they explained CF in great detail to us, including the symptoms.
<br />
<br />Upon hearing the symptoms, I brought up that I myself have experienced many, if not all of the symptoms throughout my entire life, with the exception of low weight. Many sinus issues, many hosptial stays with lung infections, many bouts with heavy mucus, etc...
<br />
<br />They had me tested and showed only one mutated gene, but they explained that I might have polymorphisms. They then explained that this would/could give me many symptoms of CF without actually having full blown CF (2 muatated genes). They did not recommend that I look into this further becaus eof several reasons. One is that my lung issues have gotten better through the years, not worse. Two is that I weighed (at that time) 275 lbs at 6 feet tall, no issues with digestion. Three is that my lungs looked great in an X-ray.
<br />
<br />Still though, salt makes me feel a lot better. I get massive sinus infections constantly, etc.. so I do wonder sometimes if I might actually have polymorphisms like they say.
<br />
<br />Anyway, I know this wasn't an answer but it's all I know about polymorphisms, hoped it helped a little.
<br />
That does really help. Thank you. Why is CF so confusing? And what is even more sad, is that I think at this point - I value the knowledge of this board more than I value the drs. at this point.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
That does really help. Thank you. Why is CF so confusing? And what is even more sad, is that I think at this point - I value the knowledge of this board more than I value the drs. at this point.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
That does really help. Thank you. Why is CF so confusing? And what is even more sad, is that I think at this point - I value the knowledge of this board more than I value the drs. at this point.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
That does really help. Thank you. Why is CF so confusing? And what is even more sad, is that I think at this point - I value the knowledge of this board more than I value the drs. at this point.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
Especially since they couldn't answer nor did they know what polymorphisms are.
That does really help. Thank you. Why is CF so confusing? And what is even more sad, is that I think at this point - I value the knowledge of this board more than I value the drs. at this point.
<br />
<br />This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
<br />
<br />Especially since they couldn't answer nor did they know what polymorphisms are.
<br />
<br />This Dr. is also at CHOP. But is a GI dr. So I have the results sent to the CF center there - and have them confirm whatever it is they need to confirm. I feel as though they are not sure in the results.
<br />
<br />Especially since they couldn't answer nor did they know what polymorphisms are.