Hi db,
I took Pulmozyme for about 3 or 4 years and at the same time I took Mucomyst. My new doctor actually took me off of both (adding other things). My lung function actually went up off of these meds. Pulmozyme works really well for many people -- obviously I was not one of them. And I have read that taking magnesium makes it more effective -- something I didn't know back then either.
My doctor doesn't care for Mucomyst, because it can trigger asthma. Funny, I don't remember the odor (rotten egg smell), but since every one says it's strong, you can see why it would irritate the lungs.
I tried Guafenisin when it was a prescription drug and it also did nothing to help with mucus. The only thing that I ever noticed (drugwise) that helped noticeably was hypertonic saline accompanied by the Flutter. It cleans all the mucus out, so I have very little during the day.
My doctor also likes to get to the source that helps cause mucus, then when you remove the sources, the mucus production diminishes so much. I used to have tons of mucus and a chronic cough.
Nasal rinses and sprays also help clear the sinuses so there isn't dripping into the lungs which in turn produce more mucus. Allergy testing and asthma testing is also very helpful.