the only effects i've had from pulmozyme are positive ones, but now that you mention it, when i get REALLY cleaned out (which is fairly often when i'm doing everything, i have a really mild case) i get to where i feel sort of funny, it might be something completely different though. i also notice that when i'm taking it like i should every day my mucus isn't only thinner, it has a little bit of a different color and (this is gross, but...) it tastes a little different, i know you get it out asap but you still taste it sometimes