Preseed is the only lubricant that aids in getting pregnant. Some or most CF'ers have hostile Cervical Mucus that keeps the sperm from swimming where it needs to go. So instead of all the other lubs that have spermicide this one doesn't and helps them get to where they need to go. Caroline on this site turned me on to it! Sadly it didn't work for me, maybe if I'd stuck with it longer. I just want to make the most of my health that I have now and be as aggressive as I can with getting pregnant. Chances are an IUI would do the trick for you though. I'd ask your CF doc, my old doc was pretty amazing and supportive. Hopefully you'll get the same response!