Resistant to every drug - Is this possible? Need help again!!

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Asexyblond23

New member
Thank you to all of you who told me to go to the ER. I did last night but nothing good came out of it, except the did move my CF appt to March 19th. The doctor did not want to admit me due to the fact that they would not change anything on the drugs im on or give me anything for pseaudo because I showed resistant to EVERY DRUG except colistion. I dont understand how on Dec 1st I can show resistant to 3 drugs in my TN culture but on Feb 12th in WA I show resistant to everything. Has anyone had this happen before? All the sudden you show resistatnt to everything??? The doctor in the er not a cf doc said she would not put me on anything for pseaudo because in seattle they are very sparing with IV drugs because this happens. You become resistant to everything. She told me this is a big worry. Serisouly can this happen? I have no drug that can treat my pseaudo and I will just get worse and worse from now on? I am really baffled by this and super upset. Its like they are telling me well your sick and dying but nothing we can treat you with. They got a culture last night at the er which I am so thankful for because I want to see what it says. Can this really happen where you become resisitant to everything for pseaudo and staff? What do you do?
 
A

Asexyblond23

New member
Thank you to all of you who told me to go to the ER. I did last night but nothing good came out of it, except the did move my CF appt to March 19th. The doctor did not want to admit me due to the fact that they would not change anything on the drugs im on or give me anything for pseaudo because I showed resistant to EVERY DRUG except colistion. I dont understand how on Dec 1st I can show resistant to 3 drugs in my TN culture but on Feb 12th in WA I show resistant to everything. Has anyone had this happen before? All the sudden you show resistatnt to everything??? The doctor in the er not a cf doc said she would not put me on anything for pseaudo because in seattle they are very sparing with IV drugs because this happens. You become resistant to everything. She told me this is a big worry. Serisouly can this happen? I have no drug that can treat my pseaudo and I will just get worse and worse from now on? I am really baffled by this and super upset. Its like they are telling me well your sick and dying but nothing we can treat you with. They got a culture last night at the er which I am so thankful for because I want to see what it says. Can this really happen where you become resisitant to everything for pseaudo and staff? What do you do?
 
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Keepercjr

Guest
Alisha

I'm so sorry. I have occasionally shown resistant to everything as well - and I have only been on IVs a handful of times ever. My CF docs have said that they will have to be very careful if and when I need IVs again. The thing is that sensitivites change all the time. Also just because you are resistant to drug A and drug B does not mean that the *combination* of drug A and B together won't work. Don't give up!!!
 
K

Keepercjr

Guest
Alisha

I'm so sorry. I have occasionally shown resistant to everything as well - and I have only been on IVs a handful of times ever. My CF docs have said that they will have to be very careful if and when I need IVs again. The thing is that sensitivites change all the time. Also just because you are resistant to drug A and drug B does not mean that the *combination* of drug A and B together won't work. Don't give up!!!
 
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Havoc

New member
Yes it is possible. MDRPA has been a problem for a long time especially in ICU's and burn units. Recently there has been interest in XDRPA (extremely drug resistant Pesudomonas Areuginosa). Historically in the course of things when you become very resistant to multiple drugs, colistin is kind of an ace in the hole as not many patients are resistant to it. The problem is that colistin is very toxic. In any case, there has been some studies done (in Singapore, I think) about how to best deal with XDRPA. Usually it involves genotyping the isolates and then a combination therapy of at least 3 antibiotics. The genotype will determine which antibiotics can be used to successfully treat XDRPA, or whether it can be treated successfully at all. This may be above even the CF docs and you should probably be thinking about an ID consult, especially if the latest sensitivity study confirms extreme resistance.
 
H

Havoc

New member
Yes it is possible. MDRPA has been a problem for a long time especially in ICU's and burn units. Recently there has been interest in XDRPA (extremely drug resistant Pesudomonas Areuginosa). Historically in the course of things when you become very resistant to multiple drugs, colistin is kind of an ace in the hole as not many patients are resistant to it. The problem is that colistin is very toxic. In any case, there has been some studies done (in Singapore, I think) about how to best deal with XDRPA. Usually it involves genotyping the isolates and then a combination therapy of at least 3 antibiotics. The genotype will determine which antibiotics can be used to successfully treat XDRPA, or whether it can be treated successfully at all. This may be above even the CF docs and you should probably be thinking about an ID consult, especially if the latest sensitivity study confirms extreme resistance.
 
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semperfiohana

Guest
call your old clinic to see what exactly the cultures said.
 
S

semperfiohana

Guest
call your old clinic to see what exactly the cultures said.
 
A

Asexyblond23

New member
I have all my culture resuluts for the past 3 years. I had a culture taken last night at the Er so I am praying that this one is better
 
A

Asexyblond23

New member
I have all my culture resuluts for the past 3 years. I had a culture taken last night at the Er so I am praying that this one is better
 
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