Anyone else here have severe large airway chronic asthma? Its really kicking my butt right now to the point where I can barely take any inhaled meds since I am so hyperreactive. Any suggestions? IgE is normal, neutophils quite high. FEV 58%, but O2 hanging out between 92-95, drops to 88/89 during exertion, around 90/91 for sleep. Two years ago w/only mild asthma I ran a 10K with this same FEV. Now stairs wind me badly. Please help! Prednisone helps, but only a high dose and dont want to be on it for years. Docs are suggesting low dose methyltrexate. Any experience with this, anyone?