Last year I lost my 22 year old cousin to CF. I am turning 27 this year, so he was not much younger than I. That is where the story starts. A couple months after he passed away, my wife and I found out we were pregnant after a long while trying. During the pregnancy my wife had a CF carrier test and found out she was a carrier of DF508. I did not know if I was a carrier or not, but I knew it was very possible because of my cousin, and I knew the odds if I was. I prayed daily for a healthy baby. So fast forward to March 2008 a few weeks after the birth of my beautiful baby boy. I was in NYC for a business incentive trip and my wife was at home with the newborn. She made the phone call to me while I was out to lunch with a VP. She was upset and told me the the NY CF screen test came back with high IRT levels. I immediately spent my night googling IRT levels and chances of that meaning my son would have CF. Well, the sweat test confirmed that my son has CF. WOW, how difficult was it to utter those words to my recently heartbroken family. I am not an overly religious person but I believe in God and I consider myself and my wife ProLife at least for our decisions. My son is a blessing and I wouldn't give him back. This is my first post so excuse the preliminaries, but this post is my reason for joining. I am having a tough time deciding if it would be ethically right to have more children. Is it right to know the 1 in 4 chance of your child having CF and knowing the risks and still having a second child? Family is quick to tell you that maybe having 1 child is fine...you know what they are thinking. My wife and I always thought we would have 3 kids. Sure there is adoption, and the use of only one set of our genes. Those are options. But here's a new issue. If you would combine either of our gene's with someone elses who's do we use? Or if we use our own and then have them test for CF in the lab before implantation,and then stop due to them finding CF is that just the same as abortion? My issue is that we would like more kids...I just do not want to feel as if my next baby was born with CF and I knew the risk, that I wouldn't feel guilty thinking in that case I could've prevented it. So to sum it up, how can I feel comfortable having more biological children even know NOW I know my own risk?