Siblings without CF

___Hannah20___

New member
My parents had three kids including me..so I have a brother and a sister without CF. My mom has a friend with two kids that both have CF tho..how does that happen? I mean my parents have the gene..so how come my brother and sister don't have it and I do?
 

Aboveallislove

Super Moderator
Dear Hannah,
CF is caused by having 2 copies of the "CF" gene that have CF mutations. Each person has two. You mom has two, one with a mutation and one without. Your dad has two, one with a mutation and one without. You received one gene from your mom and one from your dad. You receive the one from your mom that had the CF mutation and you received the one from your dad with the CF mutation. Your sibblings may have received one CF mutation from either your mom or your dad, but then they received one without a mutation from the other--or they received one mutation from each without mutations. If they are tested, they would then know if they are "carriers," meaning they have one CF gene. Both of your parents are CF carriers. There is a 25% chance for each child to have CF because there are 4 different possibilities for each child: 2 normal; 2 CF; 1 normal from mom and 1 CF from dad; and 1 CF from mom and 1 normal from dad. There is no way to determine which you'll get, just like eye color. hugs
 

erock77

Member
It's simply a gamble. Having two kids with CF is just like flipping 2 coins and they both land on heads twice, except with more sex and less coins.
 
W

welshwitch

Guest
LOL erock! Totally.

My parents took the "gamble" with my younger brother....he doesn't have CF. I remember how elated they were when they found out he was healthy.
 

SaraNoH

New member
Yeah, then it can be really bad. I know of a family that has 5 children, all with CF. I think I'd call it quits after the 2nd one... and then you get into the odds of someone with CF having a kid with a carrier and it gets ugly. My cousin is dating a guy with CF and they wont even talk about that yet because it's a bit scary to think about.
 
Top