might constipate the dog, but then again, i've never given a dog enzymes... that i know of, the dog might have gotten one off the floor that i dropped i dunno, heck i've given my dog a benadryl one time when she wouldn't settle down and go to sleep and i had to go to bed which means the dog has to go settle down and leave me alone. Its matabolized in the kidneys so as long as they have a lot of water, it will just go on though without hurting the dog, made her go to sleep though