I never miss my oral meds, Its the other things i can be lax with. I use my Albuterol & Advair everyday, because without them i would notice an immediate difference. I am 99% compliant with Pulmozyme, and about 90% with the vest. Some days i just dont feel like it and i skip it . Exercise, i am about 50% compliant with, mainly because i am active and sometimes think i can skip it since i worked that day or went out and did something that included a lot of walking.