I posted this back on 11/6/07 under a hearing loss discussion. Hearing loss is not the only sign of ear damage. Your kidneys may recover just fine after Tobra iv but you could have still suffered ear damage. Below is what I previously posted...
I never noticed any problems with my hearing after years of nebulized tobi and tobra(nebulized). However, after my first round on IV tobra ever I noticed within weeks bouncy vision (oscillopsia)
"Oscillopsia can also be used as a quantitative test to document aminoglycoside toxicity."
As I walked down the sidewalk signs and peoples faces would bounce or vibrate so I could not make them out. This is due to nerve cells in the ears that have been damaged which are now unable to properly tell your brain that your head and body are in motion. Therefore your brain does not know you are in motion and does not make the proper adjustments for the visual signals you are receiving.
I also have some degree of vertigo (balance issues) b/c my nerve cells in my ears are not keeping me in balance. Sometimes I lose my balance on stairs and especially in the dark.
This all improved alot after stopping IV Tobra. But it did not correct completely. Also I believe I am more sensitive to this with every subsequent IV Tobra course.
I have not had any actual hearing challenges from IV Tobra thank god.
What you all have described is very concerning.
My only drawbacks are that I stumble more than I should and people think I must be drunk. Also my ability to play sports well is impaired.
I would think that an IV aminoglycoside should be carefully considered if you have ear damage. If your bugs may be sensitive to a non-aminoglycoside then the non-aminoglycoside should be cosidered. Also, maybe step up the nebulized Tobi before jumping into the more systemic IV tobra.