We did pulmozyme with the vest, although now that our son is on hyper-sal, we do Xopenex and hyper-sal with the vest, then have breakfast and then pulmozyme after. He can't take the vest after any food so that's the best we can do to get treatments done and him eating at a decent hour. I understand you aren't suppose to do inhalled antibiotics with the vest. What sorts of stuff do you do with your son when doing vest? Maybe chess? Board games? computer time? Our son is only 3.5 so our things are different so mostly videos, but I'll let you use that time for "cut" time with a scissors for a treat if he is really fussing. Not sure what might work, but hopefully others have some ideas how to make the time go faster.