When ds started orkambi he had a stuffy nose, cold like symptoms and digestive issues. Very loose stools, liquid for several days. Being his main cf symptoms were digestive and sinus and he never really had a cough unless sick, figured that was his purge. When he switched to symdeko he had a drier cough, which he said was mainly that it felt different to breathe and he was seeing if he could cough anything up. And a few days of tiredness and headaches