Annalisa, she is not. I know that her mutation suggests that she SHOULD be, but she isn't. Her sweat test also came back through the roof, and that was also a bit unexpected for her R347P mutation. Are you pancreatic sufficient?
We attended the Annual CF dinner on Saturday night and Dr. Beall spoke about their efforts at increasing the percentage of patients benefiting from Kalydeco from 4% to 10, 15, even 20%. He didn't mention which mutations they're targeting for this, but I'm wondering if it might be some Class IVs, since the protein for them is already in the correct place.
I was so encouraged listening to him speak, because they are NOT just waiting to see if the combined vx-809 with Kalydeco will work with DF508 ... they are still aggressively pursuing many different compounds. It is nice to know that they have many things in the pipeline and they aren't resting solely on the vx-809/Kalydeco study. That said, hopefully that one will be successful and we won't need further compounds! <img src="i/expressions/face-icon-small-smile.gif" border="0">