VX 770

M

marcijo

Guest
I am DF508 and R117H. I just read this on a link someone had to the VX770 drug....


<div class="FTQUOTE"><begin quote>VX 770 is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and <b>R117H</b> forms of human CFTR. Based on in vitro studies and pharmacologic, pharmacokinetic (PK), and safety profiles, VX 770 has been selected for clinical development as a possible treatment for patients with CF.</end quote></div>
 
M

marcijo

Guest
I am DF508 and R117H. I just read this on a link someone had to the VX770 drug....


<div class="FTQUOTE"><begin quote>VX 770 is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and <b>R117H</b> forms of human CFTR. Based on in vitro studies and pharmacologic, pharmacokinetic (PK), and safety profiles, VX 770 has been selected for clinical development as a possible treatment for patients with CF.</end quote></div>
 
M

marcijo

Guest
I am DF508 and R117H. I just read this on a link someone had to the VX770 drug....


<div class="FTQUOTE"><begin quote>VX 770 is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and <b>R117H</b> forms of human CFTR. Based on in vitro studies and pharmacologic, pharmacokinetic (PK), and safety profiles, VX 770 has been selected for clinical development as a possible treatment for patients with CF.</end quote></div>
 
M

marcijo

Guest
I am DF508 and R117H. I just read this on a link someone had to the VX770 drug....


<div class="FTQUOTE"><begin quote>VX 770 is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and <b>R117H</b> forms of human CFTR. Based on in vitro studies and pharmacologic, pharmacokinetic (PK), and safety profiles, VX 770 has been selected for clinical development as a possible treatment for patients with CF.</end quote>
 
M

marcijo

Guest
I am DF508 and R117H. I just read this on a link someone had to the VX770 drug....


<div class="FTQUOTE"><begin quote>VX 770 is a potent and selective CFTR potentiator of wild-type, G551D, F508del, and <b>R117H</b> forms of human CFTR. Based on in vitro studies and pharmacologic, pharmacokinetic (PK), and safety profiles, VX 770 has been selected for clinical development as a possible treatment for patients with CF.</end quote>
 
J

Jeana

New member
First of all, here is the link to the CF Foundation's frequently asked question page for VX 770.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/research/ClinicalResearch/FAQs/VX-770/
">http://www.cff.org/research/Cl...Research/FAQs/VX-770/
</a>
The following statement is taken from that page:
"Vertex Pharmaceuticals is developing two oral compounds designed to treat the basic defect in cystic fibrosis - a faulty gene and its protein product, called CFTR.

VX-770, the most advanced of the two compounds, is known as a potentiator and is designed to allow CFTR located at the cell surface to function correctly."

Feel free to PM me with any questions.
 
J

Jeana

New member
First of all, here is the link to the CF Foundation's frequently asked question page for VX 770.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/research/ClinicalResearch/FAQs/VX-770/
">http://www.cff.org/research/Cl...Research/FAQs/VX-770/
</a>
The following statement is taken from that page:
"Vertex Pharmaceuticals is developing two oral compounds designed to treat the basic defect in cystic fibrosis - a faulty gene and its protein product, called CFTR.

VX-770, the most advanced of the two compounds, is known as a potentiator and is designed to allow CFTR located at the cell surface to function correctly."

Feel free to PM me with any questions.
 
J

Jeana

New member
First of all, here is the link to the CF Foundation's frequently asked question page for VX 770.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/research/ClinicalResearch/FAQs/VX-770/
">http://www.cff.org/research/Cl...Research/FAQs/VX-770/
</a>
The following statement is taken from that page:
"Vertex Pharmaceuticals is developing two oral compounds designed to treat the basic defect in cystic fibrosis - a faulty gene and its protein product, called CFTR.

VX-770, the most advanced of the two compounds, is known as a potentiator and is designed to allow CFTR located at the cell surface to function correctly."

Feel free to PM me with any questions.
 
J

Jeana

New member
First of all, here is the link to the CF Foundation's frequently asked question page for VX 770.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/research/ClinicalResearch/FAQs/VX-770/
">http://www.cff.org/research/Cl...Research/FAQs/VX-770/
</a>
The following statement is taken from that page:
"Vertex Pharmaceuticals is developing two oral compounds designed to treat the basic defect in cystic fibrosis - a faulty gene and its protein product, called CFTR.

VX-770, the most advanced of the two compounds, is known as a potentiator and is designed to allow CFTR located at the cell surface to function correctly."

Feel free to PM me with any questions.
 
J

Jeana

New member
First of all, here is the link to the CF Foundation's frequently asked question page for VX 770.
<br />
<br /><a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/research/ClinicalResearch/FAQs/VX-770/
">http://www.cff.org/research/Cl...Research/FAQs/VX-770/
</a><br />
<br />The following statement is taken from that page:
<br />"Vertex Pharmaceuticals is developing two oral compounds designed to treat the basic defect in cystic fibrosis - a faulty gene and its protein product, called CFTR.
<br />
<br />VX-770, the most advanced of the two compounds, is known as a potentiator and is designed to allow CFTR located at the cell surface to function correctly."
<br />
<br />Feel free to PM me with any questions.
 
M

marcijo

Guest
Well-I meant because my other genotype is R117H - so I have one DF508 and one R117H.....when I was reading the drug info there and saw that R117H - I wonder what this means for my genotyping....

I will go check out the FAQ's you put a link to-thanks! Not sure it will say anything about R117H though.....
 
M

marcijo

Guest
Well-I meant because my other genotype is R117H - so I have one DF508 and one R117H.....when I was reading the drug info there and saw that R117H - I wonder what this means for my genotyping....

I will go check out the FAQ's you put a link to-thanks! Not sure it will say anything about R117H though.....
 
M

marcijo

Guest
Well-I meant because my other genotype is R117H - so I have one DF508 and one R117H.....when I was reading the drug info there and saw that R117H - I wonder what this means for my genotyping....

I will go check out the FAQ's you put a link to-thanks! Not sure it will say anything about R117H though.....
 
M

marcijo

Guest
Well-I meant because my other genotype is R117H - so I have one DF508 and one R117H.....when I was reading the drug info there and saw that R117H - I wonder what this means for my genotyping....

I will go check out the FAQ's you put a link to-thanks! Not sure it will say anything about R117H though.....
 
M

marcijo

Guest
Well-I meant because my other genotype is R117H - so I have one DF508 and one R117H.....when I was reading the drug info there and saw that R117H - I wonder what this means for my genotyping....
<br />
<br />I will go check out the FAQ's you put a link to-thanks! Not sure it will say anything about R117H though.....
 
K

kitomd21

New member
Doesn't matter what it says about R117H. All that matters is that at least one of your mutations falls into what they hope to be a "treatable" mutation. In essence, you would become a CF carrier...only one mutation needs to be treated for symptoms to subside.
 
K

kitomd21

New member
Doesn't matter what it says about R117H. All that matters is that at least one of your mutations falls into what they hope to be a "treatable" mutation. In essence, you would become a CF carrier...only one mutation needs to be treated for symptoms to subside.
 
K

kitomd21

New member
Doesn't matter what it says about R117H. All that matters is that at least one of your mutations falls into what they hope to be a "treatable" mutation. In essence, you would become a CF carrier...only one mutation needs to be treated for symptoms to subside.
 
K

kitomd21

New member
Doesn't matter what it says about R117H. All that matters is that at least one of your mutations falls into what they hope to be a "treatable" mutation. In essence, you would become a CF carrier...only one mutation needs to be treated for symptoms to subside.
 
K

kitomd21

New member
Doesn't matter what it says about R117H. All that matters is that at least one of your mutations falls into what they hope to be a "treatable" mutation. In essence, you would become a CF carrier...only one mutation needs to be treated for symptoms to subside.
 
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