My doctor also is fine with me working with my PICC line in. I've been doing it for many years now and never had a problem. Of course, I always take time off at the beginning to rest up until I'm feeling strong enough to go back to work. And, my office is terrific about accommodating a reduced work schedule and telecommuting. I am blessed in that sense. I would go nuts staying at home the entire time! I think it all depends on the person and how bad the flareup is. Each person needs to do what works best for him or her - cf is NOT a one size fits all disease.