Xolair

D

dramamama

New member
hi guys-
just wanted to add that when xolair was tested, those included in different studies had to have IgE of 30 to 700. If you have asthma component to your cf, you have very reactive skin test and have been prescribed immunotherapy for your allergies, you are allergic to many cf antibiotics, you have an IgE over 30, have been diagnosed with ABPA, or take inhaled steroids to combat reactive airway disease related to inhaled allergens...you are a candidate for xolair.

Another way my cf doc tests for histamine release is by scratching my back or stomach skin. he does three line scratches. In a matter of minutes, the lines are raised and red on me due to histamine release....an IgE mediated response.

Keep in mind, xolair has just been given the black label warning by the FDA for causing severe allergic reaction in some taking the drug...definition of irony<img src="i/expressions/face-icon-small-smile.gif" border="0"> Having said that, I am currently seeking the use of this drug to combat my allergy induced asthma.
 
D

dramamama

New member
hi guys-
just wanted to add that when xolair was tested, those included in different studies had to have IgE of 30 to 700. If you have asthma component to your cf, you have very reactive skin test and have been prescribed immunotherapy for your allergies, you are allergic to many cf antibiotics, you have an IgE over 30, have been diagnosed with ABPA, or take inhaled steroids to combat reactive airway disease related to inhaled allergens...you are a candidate for xolair.

Another way my cf doc tests for histamine release is by scratching my back or stomach skin. he does three line scratches. In a matter of minutes, the lines are raised and red on me due to histamine release....an IgE mediated response.

Keep in mind, xolair has just been given the black label warning by the FDA for causing severe allergic reaction in some taking the drug...definition of irony<img src="i/expressions/face-icon-small-smile.gif" border="0"> Having said that, I am currently seeking the use of this drug to combat my allergy induced asthma.
 
D

dramamama

New member
hi guys-
just wanted to add that when xolair was tested, those included in different studies had to have IgE of 30 to 700. If you have asthma component to your cf, you have very reactive skin test and have been prescribed immunotherapy for your allergies, you are allergic to many cf antibiotics, you have an IgE over 30, have been diagnosed with ABPA, or take inhaled steroids to combat reactive airway disease related to inhaled allergens...you are a candidate for xolair.

Another way my cf doc tests for histamine release is by scratching my back or stomach skin. he does three line scratches. In a matter of minutes, the lines are raised and red on me due to histamine release....an IgE mediated response.

Keep in mind, xolair has just been given the black label warning by the FDA for causing severe allergic reaction in some taking the drug...definition of irony<img src="i/expressions/face-icon-small-smile.gif" border="0"> Having said that, I am currently seeking the use of this drug to combat my allergy induced asthma.
 
D

dramamama

New member
hi guys-
just wanted to add that when xolair was tested, those included in different studies had to have IgE of 30 to 700. If you have asthma component to your cf, you have very reactive skin test and have been prescribed immunotherapy for your allergies, you are allergic to many cf antibiotics, you have an IgE over 30, have been diagnosed with ABPA, or take inhaled steroids to combat reactive airway disease related to inhaled allergens...you are a candidate for xolair.

Another way my cf doc tests for histamine release is by scratching my back or stomach skin. he does three line scratches. In a matter of minutes, the lines are raised and red on me due to histamine release....an IgE mediated response.

Keep in mind, xolair has just been given the black label warning by the FDA for causing severe allergic reaction in some taking the drug...definition of irony<img src="i/expressions/face-icon-small-smile.gif" border="0"> Having said that, I am currently seeking the use of this drug to combat my allergy induced asthma.
 
D

dramamama

New member
hi guys-
<br />just wanted to add that when xolair was tested, those included in different studies had to have IgE of 30 to 700. If you have asthma component to your cf, you have very reactive skin test and have been prescribed immunotherapy for your allergies, you are allergic to many cf antibiotics, you have an IgE over 30, have been diagnosed with ABPA, or take inhaled steroids to combat reactive airway disease related to inhaled allergens...you are a candidate for xolair.
<br />
<br />Another way my cf doc tests for histamine release is by scratching my back or stomach skin. he does three line scratches. In a matter of minutes, the lines are raised and red on me due to histamine release....an IgE mediated response.
<br />
<br />Keep in mind, xolair has just been given the black label warning by the FDA for causing severe allergic reaction in some taking the drug...definition of irony<img src="i/expressions/face-icon-small-smile.gif" border="0"> Having said that, I am currently seeking the use of this drug to combat my allergy induced asthma.
<br />
<br />
<br />
 
E

etabetac

New member
Catboogie, we see the same two clinics according to what you posted on the Raleigh/Durham thread. The allergist I see said he recommends Xolair based on my IgE (I believe I was in 600 range last check) but we are holding off for now because there is some concern about usefulness, reactions, and not a lot of research. Haven't talked to pulmo about it yet but it's interesting that the pulmo is the one who initiated the discussion and not the other way around. But then again my allergy/asthma component is far worse than anything else going on in this body.

As for allergy shots, it's good you started them before the spring. You should start seeing some results for the spring/summer.
 
E

etabetac

New member
Catboogie, we see the same two clinics according to what you posted on the Raleigh/Durham thread. The allergist I see said he recommends Xolair based on my IgE (I believe I was in 600 range last check) but we are holding off for now because there is some concern about usefulness, reactions, and not a lot of research. Haven't talked to pulmo about it yet but it's interesting that the pulmo is the one who initiated the discussion and not the other way around. But then again my allergy/asthma component is far worse than anything else going on in this body.

As for allergy shots, it's good you started them before the spring. You should start seeing some results for the spring/summer.
 
E

etabetac

New member
Catboogie, we see the same two clinics according to what you posted on the Raleigh/Durham thread. The allergist I see said he recommends Xolair based on my IgE (I believe I was in 600 range last check) but we are holding off for now because there is some concern about usefulness, reactions, and not a lot of research. Haven't talked to pulmo about it yet but it's interesting that the pulmo is the one who initiated the discussion and not the other way around. But then again my allergy/asthma component is far worse than anything else going on in this body.

As for allergy shots, it's good you started them before the spring. You should start seeing some results for the spring/summer.
 
E

etabetac

New member
Catboogie, we see the same two clinics according to what you posted on the Raleigh/Durham thread. The allergist I see said he recommends Xolair based on my IgE (I believe I was in 600 range last check) but we are holding off for now because there is some concern about usefulness, reactions, and not a lot of research. Haven't talked to pulmo about it yet but it's interesting that the pulmo is the one who initiated the discussion and not the other way around. But then again my allergy/asthma component is far worse than anything else going on in this body.

As for allergy shots, it's good you started them before the spring. You should start seeing some results for the spring/summer.
 
E

etabetac

New member
Catboogie, we see the same two clinics according to what you posted on the Raleigh/Durham thread. The allergist I see said he recommends Xolair based on my IgE (I believe I was in 600 range last check) but we are holding off for now because there is some concern about usefulness, reactions, and not a lot of research. Haven't talked to pulmo about it yet but it's interesting that the pulmo is the one who initiated the discussion and not the other way around. But then again my allergy/asthma component is far worse than anything else going on in this body.
<br />
<br />As for allergy shots, it's good you started them before the spring. You should start seeing some results for the spring/summer.
 
D

dramamama

New member
Hi Again-
I also wanted to add this VERY interesting article about a cfer with cepacia and xolair. Her cepacia was resistant to all but one antibiotic...one she was extremely allergic to (meropenam). After two failed attempts at desensitization, they succeeded only after she was treated with xolair. I, too, have failed the desensitization of a drug, so this is like Christmas for me.



Successful Intravenous "Rush" Drug Desensitization to Meropenam Following Omalizumab Administration

Article Outline
RATIONALE: Severe drug allergy may be encountered in cystic fibrosis and other diseases in which patients are exposed to multiple courses of antibiotics. "Rush" drug desensitization is often necessary in such cases, but can lead to severe and potentially life-threatening allergic reactions. Although only approved for the treatment of allergic asthma, the anti-IgE monoclonal antibody omalizumab should in theory reduce reactivity to any or all IgE-mediated allergic responses, including those to drugs.

METHODS: We report our experience in the treatment of a fifteen year old girl with a history of allergy to multiple antibiotics including meropenam, who was hospitalized for a pulmonary exascerbation of cystic fibrosis. Sputum cultures revealed multiple strains of Burkholderia cepacia highly sensitive only to meropenam. Because the patient had poorly controlled allergic asthma with perennial triggers and an elevated IgE level, omalizumab therapy had been initiated six months earlier. Two previous attempts at meropenam desensitization had failed due to severe systemic reactions which occurred at a dose of only 10 mg.

RESULTS: Following omalizumab administration, the patient was desensitized successfully to meropenam. She experienced only mild symptoms at a dose of 320 mg, and then received a total dose of 1000 mg without incident. Further evidence of IgE-mediated reactivity to meropenam was not noted during her subsequent course of treatment with the drug.

CONCLUSIONS: This case suggests that omalizumab may be efficacious in the treatment of severe IgE-mediated drug allergy, and may reduce the risk associated with "rush" drug desensitization.

1 Internal Medicine, and Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
2 Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
3 Emergency Medicine, Edward W. Sparrow Hospital, Lansing, MI
 
D

dramamama

New member
Hi Again-
I also wanted to add this VERY interesting article about a cfer with cepacia and xolair. Her cepacia was resistant to all but one antibiotic...one she was extremely allergic to (meropenam). After two failed attempts at desensitization, they succeeded only after she was treated with xolair. I, too, have failed the desensitization of a drug, so this is like Christmas for me.



Successful Intravenous "Rush" Drug Desensitization to Meropenam Following Omalizumab Administration

Article Outline
RATIONALE: Severe drug allergy may be encountered in cystic fibrosis and other diseases in which patients are exposed to multiple courses of antibiotics. "Rush" drug desensitization is often necessary in such cases, but can lead to severe and potentially life-threatening allergic reactions. Although only approved for the treatment of allergic asthma, the anti-IgE monoclonal antibody omalizumab should in theory reduce reactivity to any or all IgE-mediated allergic responses, including those to drugs.

METHODS: We report our experience in the treatment of a fifteen year old girl with a history of allergy to multiple antibiotics including meropenam, who was hospitalized for a pulmonary exascerbation of cystic fibrosis. Sputum cultures revealed multiple strains of Burkholderia cepacia highly sensitive only to meropenam. Because the patient had poorly controlled allergic asthma with perennial triggers and an elevated IgE level, omalizumab therapy had been initiated six months earlier. Two previous attempts at meropenam desensitization had failed due to severe systemic reactions which occurred at a dose of only 10 mg.

RESULTS: Following omalizumab administration, the patient was desensitized successfully to meropenam. She experienced only mild symptoms at a dose of 320 mg, and then received a total dose of 1000 mg without incident. Further evidence of IgE-mediated reactivity to meropenam was not noted during her subsequent course of treatment with the drug.

CONCLUSIONS: This case suggests that omalizumab may be efficacious in the treatment of severe IgE-mediated drug allergy, and may reduce the risk associated with "rush" drug desensitization.

1 Internal Medicine, and Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
2 Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
3 Emergency Medicine, Edward W. Sparrow Hospital, Lansing, MI
 
D

dramamama

New member
Hi Again-
I also wanted to add this VERY interesting article about a cfer with cepacia and xolair. Her cepacia was resistant to all but one antibiotic...one she was extremely allergic to (meropenam). After two failed attempts at desensitization, they succeeded only after she was treated with xolair. I, too, have failed the desensitization of a drug, so this is like Christmas for me.



Successful Intravenous "Rush" Drug Desensitization to Meropenam Following Omalizumab Administration

Article Outline
RATIONALE: Severe drug allergy may be encountered in cystic fibrosis and other diseases in which patients are exposed to multiple courses of antibiotics. "Rush" drug desensitization is often necessary in such cases, but can lead to severe and potentially life-threatening allergic reactions. Although only approved for the treatment of allergic asthma, the anti-IgE monoclonal antibody omalizumab should in theory reduce reactivity to any or all IgE-mediated allergic responses, including those to drugs.

METHODS: We report our experience in the treatment of a fifteen year old girl with a history of allergy to multiple antibiotics including meropenam, who was hospitalized for a pulmonary exascerbation of cystic fibrosis. Sputum cultures revealed multiple strains of Burkholderia cepacia highly sensitive only to meropenam. Because the patient had poorly controlled allergic asthma with perennial triggers and an elevated IgE level, omalizumab therapy had been initiated six months earlier. Two previous attempts at meropenam desensitization had failed due to severe systemic reactions which occurred at a dose of only 10 mg.

RESULTS: Following omalizumab administration, the patient was desensitized successfully to meropenam. She experienced only mild symptoms at a dose of 320 mg, and then received a total dose of 1000 mg without incident. Further evidence of IgE-mediated reactivity to meropenam was not noted during her subsequent course of treatment with the drug.

CONCLUSIONS: This case suggests that omalizumab may be efficacious in the treatment of severe IgE-mediated drug allergy, and may reduce the risk associated with "rush" drug desensitization.

1 Internal Medicine, and Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
2 Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
3 Emergency Medicine, Edward W. Sparrow Hospital, Lansing, MI
 
D

dramamama

New member
Hi Again-
I also wanted to add this VERY interesting article about a cfer with cepacia and xolair. Her cepacia was resistant to all but one antibiotic...one she was extremely allergic to (meropenam). After two failed attempts at desensitization, they succeeded only after she was treated with xolair. I, too, have failed the desensitization of a drug, so this is like Christmas for me.



Successful Intravenous "Rush" Drug Desensitization to Meropenam Following Omalizumab Administration

Article Outline
RATIONALE: Severe drug allergy may be encountered in cystic fibrosis and other diseases in which patients are exposed to multiple courses of antibiotics. "Rush" drug desensitization is often necessary in such cases, but can lead to severe and potentially life-threatening allergic reactions. Although only approved for the treatment of allergic asthma, the anti-IgE monoclonal antibody omalizumab should in theory reduce reactivity to any or all IgE-mediated allergic responses, including those to drugs.

METHODS: We report our experience in the treatment of a fifteen year old girl with a history of allergy to multiple antibiotics including meropenam, who was hospitalized for a pulmonary exascerbation of cystic fibrosis. Sputum cultures revealed multiple strains of Burkholderia cepacia highly sensitive only to meropenam. Because the patient had poorly controlled allergic asthma with perennial triggers and an elevated IgE level, omalizumab therapy had been initiated six months earlier. Two previous attempts at meropenam desensitization had failed due to severe systemic reactions which occurred at a dose of only 10 mg.

RESULTS: Following omalizumab administration, the patient was desensitized successfully to meropenam. She experienced only mild symptoms at a dose of 320 mg, and then received a total dose of 1000 mg without incident. Further evidence of IgE-mediated reactivity to meropenam was not noted during her subsequent course of treatment with the drug.

CONCLUSIONS: This case suggests that omalizumab may be efficacious in the treatment of severe IgE-mediated drug allergy, and may reduce the risk associated with "rush" drug desensitization.

1 Internal Medicine, and Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
2 Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
3 Emergency Medicine, Edward W. Sparrow Hospital, Lansing, MI
 
D

dramamama

New member
Hi Again-
<br />I also wanted to add this VERY interesting article about a cfer with cepacia and xolair. Her cepacia was resistant to all but one antibiotic...one she was extremely allergic to (meropenam). After two failed attempts at desensitization, they succeeded only after she was treated with xolair. I, too, have failed the desensitization of a drug, so this is like Christmas for me.
<br />
<br />
<br />
<br />Successful Intravenous "Rush" Drug Desensitization to Meropenam Following Omalizumab Administration
<br />
<br />Article Outline
<br />RATIONALE: Severe drug allergy may be encountered in cystic fibrosis and other diseases in which patients are exposed to multiple courses of antibiotics. "Rush" drug desensitization is often necessary in such cases, but can lead to severe and potentially life-threatening allergic reactions. Although only approved for the treatment of allergic asthma, the anti-IgE monoclonal antibody omalizumab should in theory reduce reactivity to any or all IgE-mediated allergic responses, including those to drugs.
<br />
<br />METHODS: We report our experience in the treatment of a fifteen year old girl with a history of allergy to multiple antibiotics including meropenam, who was hospitalized for a pulmonary exascerbation of cystic fibrosis. Sputum cultures revealed multiple strains of Burkholderia cepacia highly sensitive only to meropenam. Because the patient had poorly controlled allergic asthma with perennial triggers and an elevated IgE level, omalizumab therapy had been initiated six months earlier. Two previous attempts at meropenam desensitization had failed due to severe systemic reactions which occurred at a dose of only 10 mg.
<br />
<br />RESULTS: Following omalizumab administration, the patient was desensitized successfully to meropenam. She experienced only mild symptoms at a dose of 320 mg, and then received a total dose of 1000 mg without incident. Further evidence of IgE-mediated reactivity to meropenam was not noted during her subsequent course of treatment with the drug.
<br />
<br />CONCLUSIONS: This case suggests that omalizumab may be efficacious in the treatment of severe IgE-mediated drug allergy, and may reduce the risk associated with "rush" drug desensitization.
<br />
<br />1 Internal Medicine, and Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
<br />2 Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI
<br />3 Emergency Medicine, Edward W. Sparrow Hospital, Lansing, MI
<br />
 
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