Yale Scientist use gene editing to correct mutation!

[Imogene]

http://news.yale.edu/2015/04/27/yale-scientists-use-gene-editing-correct-mutation-cystic-fibrosis

 

[Dank]

Awesome I love seeing technology at work. Gene therapy has been around awhile though. I wonder how this is different. I remember being a teenager and knowing someone who was using gene therapy, it was my understanding the CF cells eventually overtook the healthy genes. Either way thanks for sharing!

 

[ethan508]

The difference between this therapy and therapies of the past is the delivery mechanism. In the past researchers had thought they could use a bacteria or virus to deliver the new DNA to the lung cells, which wasn't very efficient. Now they are trying nano-molecules which I suppose, as a man-made molecule, would be a little easier to control and dose. But to be a real cure they still would need to change enough cells without adversely affecting cell replication so that you'd eventually have a critical mass of good cells to overcome the bad ones. Even without reaching critical mass it might still be a very good therapy. Fascinating stuff really. I hope it continues to show promise.

 

[Aboveallislove]

Crispr cas9 sounds like the best most advanced potential for a cure re gene editing. http://www.nature.com/nm/journal/v20/n5/full/nm.3566.html. There a ton being done and absolutely amazing.

 

[Aboveallislove]

Here's a great summary of Crispr cas 9: http://cysticfibrosisnewstoday.com/...-cas9-be-used-to-replace-mutated-genes-in-cf/

Thanks so much Jeanne for posting that original article. I hadn't seen that and I wonder if it is similar or not. As Ethan says, this is really fascinating stuff.

 

[peter]

This primer link isn't too long or particularly complicated about this kind of technology, but by no means complete.Gene therapy - Better Health Channel. Gene therapy - Better Health Channel