Hello,
I have had problems with severe reflex ever since I was 14 years old. I started on Zantac, then moved up to Prevacid, Prilosec, and now Nexium. I have even taken as much as four 40mg of Nexium a day. Luckily now I am down to only two Nexium's a day, but I have pretty much been on them all. Protonix is also available, although I have never taken that one.