My son and I got off enzymes. I have spoken with one other person whose child eventually stopped needing them. I have a few thoughts on how that happened for me and my son. The other person I talked to apparently had no idea how it happened. Since some percentage of folks start out pancreatic sufficient and become insufficient, it seems logical to me that it isn't simply "genetic" but that some process of deterioration leads to it. So presumably it is potentially reversible if sufficiently understood.