can you BECOME pancreatic sufficient?

[hmw]

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

Not everyone with CF needs enzymes- a fortunate minority are still pancreatic-sufficient and don't- and there are other factors that can contribute when people with CF have trouble gaining/maintaining their weight, outside of pancreatic function. (For example, those with CF need substantially more calories than someone without CF of the same age/height to maintain their weight.) There are supportive things that we can do that can improve the digestive process in some cases for some people... but I wanted to point out that it's not still 'theoretic' as far as why pancreatic insufficiency occurs in the first place.

And given the progressive nature of the disease, without a way to address damage already done to the pancreas, I would not be too optimistic about this at this point of CF treatment, once one has reached the point of needing enzymes. I am not saying it's impossible- only your dr could tell you that- but I don't think it's common.

 

[hmw]

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

Not everyone with CF needs enzymes- a fortunate minority are still pancreatic-sufficient and don't- and there are other factors that can contribute when people with CF have trouble gaining/maintaining their weight, outside of pancreatic function. (For example, those with CF need substantially more calories than someone without CF of the same age/height to maintain their weight.) There are supportive things that we can do that can improve the digestive process in some cases for some people... but I wanted to point out that it's not still 'theoretic' as far as why pancreatic insufficiency occurs in the first place.

And given the progressive nature of the disease, without a way to address damage already done to the pancreas, I would not be too optimistic about this at this point of CF treatment, once one has reached the point of needing enzymes. I am not saying it's impossible- only your dr could tell you that- but I don't think it's common.

 

[hmw]

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

Not everyone with CF needs enzymes- a fortunate minority are still pancreatic-sufficient and don't- and there are other factors that can contribute when people with CF have trouble gaining/maintaining their weight, outside of pancreatic function. (For example, those with CF need substantially more calories than someone without CF of the same age/height to maintain their weight.) There are supportive things that we can do that can improve the digestive process in some cases for some people... but I wanted to point out that it's not still 'theoretic' as far as why pancreatic insufficiency occurs in the first place.

And given the progressive nature of the disease, without a way to address damage already done to the pancreas, I would not be too optimistic about this at this point of CF treatment, once one has reached the point of needing enzymes. I am not saying it's impossible- only your dr could tell you that- but I don't think it's common.

 

[hmw]

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

Not everyone with CF needs enzymes- a fortunate minority are still pancreatic-sufficient and don't- and there are other factors that can contribute when people with CF have trouble gaining/maintaining their weight, outside of pancreatic function. (For example, those with CF need substantially more calories than someone without CF of the same age/height to maintain their weight.) There are supportive things that we can do that can improve the digestive process in some cases for some people... but I wanted to point out that it's not still 'theoretic' as far as why pancreatic insufficiency occurs in the first place.

And given the progressive nature of the disease, without a way to address damage already done to the pancreas, I would not be too optimistic about this at this point of CF treatment, once one has reached the point of needing enzymes. I am not saying it's impossible- only your dr could tell you that- but I don't think it's common.

 

[hmw]

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.
<br />
<br />Not everyone with CF needs enzymes- a fortunate minority are still pancreatic-sufficient and don't- and there are other factors that can contribute when people with CF have trouble gaining/maintaining their weight, outside of pancreatic function. (For example, those with CF need substantially more calories than someone without CF of the same age/height to maintain their weight.) There are supportive things that we can do that can improve the digestive process in some cases for some people... but I wanted to point out that it's not still 'theoretic' as far as why pancreatic insufficiency occurs in the first place.
<br />
<br />And given the progressive nature of the disease, without a way to address damage already done to the pancreas, I would not be too optimistic about this at this point of CF treatment, once one has reached the point of needing enzymes. I am not saying it's impossible- only your dr could tell you that- but I don't think it's common.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

</end quote></div>

I'm curious: what specifically is currently believed to cause it? "Disease process" is rather vague.

Thanks in advance.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

</end quote></div>

I'm curious: what specifically is currently believed to cause it? "Disease process" is rather vague.

Thanks in advance.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

</end quote></div>

I'm curious: what specifically is currently believed to cause it? "Disease process" is rather vague.

Thanks in advance.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.

</end quote>

I'm curious: what specifically is currently believed to cause it? "Disease process" is rather vague.

Thanks in advance.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>
<br />
<br />There are known reasons for why most people with CF become pancreatic-insufficient. It is not something that is still left up in the air as far as guessing why the process occurs (i.e. is it genetic? Is it a process of deterioration?) It is part of the disease process of CF.
<br />
<br /></end quote>
<br />
<br />I'm curious: what specifically is currently believed to cause it? "Disease process" is rather vague.
<br />
<br />Thanks in advance.

 

[hmw]

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that... <img src="i/expressions/face-icon-small-confused.gif" border="0">

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption." A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."

Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something. I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.

 

[hmw]

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that... <img src="i/expressions/face-icon-small-confused.gif" border="0">

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption." A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."

Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something. I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.

 

[hmw]

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that... <img src="i/expressions/face-icon-small-confused.gif" border="0">

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption." A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."

Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something. I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.

 

[hmw]

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that... <img src="i/expressions/face-icon-small-confused.gif" border="0">

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption." A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."

Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something. I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.

 

[hmw]

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that... <img src="i/expressions/face-icon-small-confused.gif" border="0">
<br />
<br />Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption." A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."
<br />
<br />Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something. I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)
<br />
<br />At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that...

</end quote></div>
I can't say I have seen any good explanations. I was hoping you had some solid info.
<div class="FTQUOTE"><begin quote>

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption."
</end quote></div>
That definition really doesn't tell me the mechanism at the cellular/chemical level which specifically causes this.
<div class="FTQUOTE"><begin quote>
A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."
</end quote></div>
One study I read about indicates that people with CF don't produce "too much" mucus, and indicated that, instead, they produce too little and that all the gunk in their lungs is phlegm (ie infection), not mucus. This second explanation fits better with my experience and makes more logical sense to me. So, since I consider this common definition of the problem to be in error, I don't believe it explains anything about pancreatic insufficiency.
<div class="FTQUOTE"><begin quote>
Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something.
</end quote></div>
Although I have been attacked repeatedly in this forum, I don't recall doing any attacking. So I have no idea why you would think I am trying to set you up.
<div class="FTQUOTE"><begin quote>
I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)
</end quote></div>
I would appreciate any links you can provide with specific information about what is believed to cause pancreatic insufficiency in pwcf. I find that lots of studies are fundamentally flawed. But I am always interested in good information.

EDIT: I mean any info available on what they think causes someone who was pancreatic sufficient to become pancreatic insufficient. I am curious what the current mental model is for how and why that happens. I have not seen anything that indicates that anyone knows why this happens.
<div class="FTQUOTE"><begin quote>

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.</end quote></div>
Well, I am not aware of a good scientific explanation of it. Your post didn't help me understand it any better. I would still be extremely happy to get hard data on this.

Thanks for replying.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that...

</end quote></div>
I can't say I have seen any good explanations. I was hoping you had some solid info.
<div class="FTQUOTE"><begin quote>

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption."
</end quote></div>
That definition really doesn't tell me the mechanism at the cellular/chemical level which specifically causes this.
<div class="FTQUOTE"><begin quote>
A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."
</end quote></div>
One study I read about indicates that people with CF don't produce "too much" mucus, and indicated that, instead, they produce too little and that all the gunk in their lungs is phlegm (ie infection), not mucus. This second explanation fits better with my experience and makes more logical sense to me. So, since I consider this common definition of the problem to be in error, I don't believe it explains anything about pancreatic insufficiency.
<div class="FTQUOTE"><begin quote>
Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something.
</end quote></div>
Although I have been attacked repeatedly in this forum, I don't recall doing any attacking. So I have no idea why you would think I am trying to set you up.
<div class="FTQUOTE"><begin quote>
I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)
</end quote></div>
I would appreciate any links you can provide with specific information about what is believed to cause pancreatic insufficiency in pwcf. I find that lots of studies are fundamentally flawed. But I am always interested in good information.

EDIT: I mean any info available on what they think causes someone who was pancreatic sufficient to become pancreatic insufficient. I am curious what the current mental model is for how and why that happens. I have not seen anything that indicates that anyone knows why this happens.
<div class="FTQUOTE"><begin quote>

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.</end quote></div>
Well, I am not aware of a good scientific explanation of it. Your post didn't help me understand it any better. I would still be extremely happy to get hard data on this.

Thanks for replying.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that...

</end quote></div>
I can't say I have seen any good explanations. I was hoping you had some solid info.
<div class="FTQUOTE"><begin quote>

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption."
</end quote></div>
That definition really doesn't tell me the mechanism at the cellular/chemical level which specifically causes this.
<div class="FTQUOTE"><begin quote>
A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."
</end quote></div>
One study I read about indicates that people with CF don't produce "too much" mucus, and indicated that, instead, they produce too little and that all the gunk in their lungs is phlegm (ie infection), not mucus. This second explanation fits better with my experience and makes more logical sense to me. So, since I consider this common definition of the problem to be in error, I don't believe it explains anything about pancreatic insufficiency.
<div class="FTQUOTE"><begin quote>
Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something.
</end quote></div>
Although I have been attacked repeatedly in this forum, I don't recall doing any attacking. So I have no idea why you would think I am trying to set you up.
<div class="FTQUOTE"><begin quote>
I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)
</end quote></div>
I would appreciate any links you can provide with specific information about what is believed to cause pancreatic insufficiency in pwcf. I find that lots of studies are fundamentally flawed. But I am always interested in good information.

EDIT: I mean any info available on what they think causes someone who was pancreatic sufficient to become pancreatic insufficient. I am curious what the current mental model is for how and why that happens. I have not seen anything that indicates that anyone knows why this happens.
<div class="FTQUOTE"><begin quote>

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.</end quote></div>
Well, I am not aware of a good scientific explanation of it. Your post didn't help me understand it any better. I would still be extremely happy to get hard data on this.

Thanks for replying.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>

What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that...

</end quote>
I can't say I have seen any good explanations. I was hoping you had some solid info.
<div class="FTQUOTE"><begin quote>

Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption."
</end quote>
That definition really doesn't tell me the mechanism at the cellular/chemical level which specifically causes this.
<div class="FTQUOTE"><begin quote>
A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."
</end quote>
One study I read about indicates that people with CF don't produce "too much" mucus, and indicated that, instead, they produce too little and that all the gunk in their lungs is phlegm (ie infection), not mucus. This second explanation fits better with my experience and makes more logical sense to me. So, since I consider this common definition of the problem to be in error, I don't believe it explains anything about pancreatic insufficiency.
<div class="FTQUOTE"><begin quote>
Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something.
</end quote>
Although I have been attacked repeatedly in this forum, I don't recall doing any attacking. So I have no idea why you would think I am trying to set you up.
<div class="FTQUOTE"><begin quote>
I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)
</end quote>
I would appreciate any links you can provide with specific information about what is believed to cause pancreatic insufficiency in pwcf. I find that lots of studies are fundamentally flawed. But I am always interested in good information.

EDIT: I mean any info available on what they think causes someone who was pancreatic sufficient to become pancreatic insufficient. I am curious what the current mental model is for how and why that happens. I have not seen anything that indicates that anyone knows why this happens.
<div class="FTQUOTE"><begin quote>

At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.</end quote>
Well, I am not aware of a good scientific explanation of it. Your post didn't help me understand it any better. I would still be extremely happy to get hard data on this.

Thanks for replying.

 

[MicheleGazelle]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>hmw</b></i>
<br />
<br />What causes pancreatic insufficiency? Is that what you are asking me? Nearly every website/article about CF addresses that...

<br /></end quote>
<br />I can't say I have seen any good explanations. I was hoping you had some solid info.
<br /><div class="FTQUOTE"><begin quote>
<br />
<br />Pancreatic insufficiency, defined, is "the inability of the exocrine pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine and to allow its absorption."
<br /></end quote>
<br />That definition really doesn't tell me the mechanism at the cellular/chemical level which specifically causes this.
<br /><div class="FTQUOTE"><begin quote>
<br />A basic definition of why this occurs with those who have CF, according to the CFF website is "A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food."
<br /></end quote>
<br />One study I read about indicates that people with CF don't produce "too much" mucus, and indicated that, instead, they produce too little and that all the gunk in their lungs is phlegm (ie infection), not mucus. This second explanation fits better with my experience and makes more logical sense to me. So, since I consider this common definition of the problem to be in error, I don't believe it explains anything about pancreatic insufficiency.
<br /><div class="FTQUOTE"><begin quote>
<br />Since this is such a commonly known/medically accepted definition I don't quite understand where you are going with your question; whether you expect more of a response or if you are setting me up for something.
<br /></end quote>
<br />Although I have been attacked repeatedly in this forum, I don't recall doing any attacking. So I have no idea why you would think I am trying to set you up.
<br /><div class="FTQUOTE"><begin quote>
<br />I know that's only the most basic of explanations of course, but medical science has made enormous strides in understanding the more complex interactions that are taking place that cause this. (i.e. the overview of CF on the eMedicine website goes into more detail how the pancreas & digestive system is affected, as do countless other websites.)
<br /></end quote>
<br />I would appreciate any links you can provide with specific information about what is believed to cause pancreatic insufficiency in pwcf. I find that lots of studies are fundamentally flawed. But I am always interested in good information.
<br />
<br />EDIT: I mean any info available on what they think causes someone who was pancreatic sufficient to become pancreatic insufficient. I am curious what the current mental model is for how and why that happens. I have not seen anything that indicates that anyone knows why this happens.
<br /><div class="FTQUOTE"><begin quote>
<br />
<br />At any rate, my real point in posting had been to clarify that the chain reaction of events that leads to one being PI is scientifically understood, not some nebulous mystery.</end quote>
<br />Well, I am not aware of a good scientific explanation of it. Your post didn't help me understand it any better. I would still be extremely happy to get hard data on this.
<br />
<br />Thanks for replying.