cipro resistance patterns

[saveferris2009]

James, you can become resistant even after one use of Cipro. PA is a pretty virulent bug.

You can even pick up a Cipro resistant PA in your clinic, hospital, or local water source.

Antibiotics and anti bacterial products are so overused in the general population (do you have anti bacterial hand soap at home? you're contributing to the problem! use anti bacterial wipes? you're the problem again!) that it increases the resistance of abx exponentially.

 

[saveferris2009]

James, you can become resistant even after one use of Cipro. PA is a pretty virulent bug.

You can even pick up a Cipro resistant PA in your clinic, hospital, or local water source.

Antibiotics and anti bacterial products are so overused in the general population (do you have anti bacterial hand soap at home? you're contributing to the problem! use anti bacterial wipes? you're the problem again!) that it increases the resistance of abx exponentially.

 

[saveferris2009]

James, you can become resistant even after one use of Cipro. PA is a pretty virulent bug.

You can even pick up a Cipro resistant PA in your clinic, hospital, or local water source.

Antibiotics and anti bacterial products are so overused in the general population (do you have anti bacterial hand soap at home? you're contributing to the problem! use anti bacterial wipes? you're the problem again!) that it increases the resistance of abx exponentially.

 

[saveferris2009]

James, you can become resistant even after one use of Cipro. PA is a pretty virulent bug.

You can even pick up a Cipro resistant PA in your clinic, hospital, or local water source.

Antibiotics and anti bacterial products are so overused in the general population (do you have anti bacterial hand soap at home? you're contributing to the problem! use anti bacterial wipes? you're the problem again!) that it increases the resistance of abx exponentially.

 

[saveferris2009]

James, you can become resistant even after one use of Cipro. PA is a pretty virulent bug.
<br />
<br />You can even pick up a Cipro resistant PA in your clinic, hospital, or local water source.
<br />
<br />Antibiotics and anti bacterial products are so overused in the general population (do you have anti bacterial hand soap at home? you're contributing to the problem! use anti bacterial wipes? you're the problem again!) that it increases the resistance of abx exponentially.
<br />
<br />

 

[jdubbs]

I know you can pick up Cipro resistant bugs from the clinic, which honestly makes me nervous every time I go in. I have cultured PA for at least 10 years and so far I've been lucky enough to have sensitive bugs. Personally, my suspicion is that it takes a prolonged period of exposure to cipro before resistance becomes a serious problem. It's scary to think a single course of cipro would lead to resistance. I tend to think of resistance as a sort of gradual process. That said, I don't doubt there are instances of more sudden resistance. I just feel it's less likely. I have only had cipro sans tobi perhaps once, probably the first time I cultured PA. ANyway, I'm wondering if the combination has helped keep the bug sensitive, or if I'm just lucky, or what. After a cipro/tobi course, I tend to freak out a bit for a while and exercise like a mad man for as long as I can. Usually I can go about 3-6 months before I need another cipro course. ALthough, usually I have a tobi course in between. Anyway, saveferris (Amy), if you have any articles in your archives that might help in my understanding of resistance, please point me to them! As I read these boards, sometimes it seems like docs might be getting lazy and just prescribing cipro without worry of resistance. Personally I think it shoudl alwauys be accompanied with another antibiotic. Just my amateur opinion.

 

[jdubbs]

I know you can pick up Cipro resistant bugs from the clinic, which honestly makes me nervous every time I go in. I have cultured PA for at least 10 years and so far I've been lucky enough to have sensitive bugs. Personally, my suspicion is that it takes a prolonged period of exposure to cipro before resistance becomes a serious problem. It's scary to think a single course of cipro would lead to resistance. I tend to think of resistance as a sort of gradual process. That said, I don't doubt there are instances of more sudden resistance. I just feel it's less likely. I have only had cipro sans tobi perhaps once, probably the first time I cultured PA. ANyway, I'm wondering if the combination has helped keep the bug sensitive, or if I'm just lucky, or what. After a cipro/tobi course, I tend to freak out a bit for a while and exercise like a mad man for as long as I can. Usually I can go about 3-6 months before I need another cipro course. ALthough, usually I have a tobi course in between. Anyway, saveferris (Amy), if you have any articles in your archives that might help in my understanding of resistance, please point me to them! As I read these boards, sometimes it seems like docs might be getting lazy and just prescribing cipro without worry of resistance. Personally I think it shoudl alwauys be accompanied with another antibiotic. Just my amateur opinion.

 

[jdubbs]

I know you can pick up Cipro resistant bugs from the clinic, which honestly makes me nervous every time I go in. I have cultured PA for at least 10 years and so far I've been lucky enough to have sensitive bugs. Personally, my suspicion is that it takes a prolonged period of exposure to cipro before resistance becomes a serious problem. It's scary to think a single course of cipro would lead to resistance. I tend to think of resistance as a sort of gradual process. That said, I don't doubt there are instances of more sudden resistance. I just feel it's less likely. I have only had cipro sans tobi perhaps once, probably the first time I cultured PA. ANyway, I'm wondering if the combination has helped keep the bug sensitive, or if I'm just lucky, or what. After a cipro/tobi course, I tend to freak out a bit for a while and exercise like a mad man for as long as I can. Usually I can go about 3-6 months before I need another cipro course. ALthough, usually I have a tobi course in between. Anyway, saveferris (Amy), if you have any articles in your archives that might help in my understanding of resistance, please point me to them! As I read these boards, sometimes it seems like docs might be getting lazy and just prescribing cipro without worry of resistance. Personally I think it shoudl alwauys be accompanied with another antibiotic. Just my amateur opinion.

 

[jdubbs]

I know you can pick up Cipro resistant bugs from the clinic, which honestly makes me nervous every time I go in. I have cultured PA for at least 10 years and so far I've been lucky enough to have sensitive bugs. Personally, my suspicion is that it takes a prolonged period of exposure to cipro before resistance becomes a serious problem. It's scary to think a single course of cipro would lead to resistance. I tend to think of resistance as a sort of gradual process. That said, I don't doubt there are instances of more sudden resistance. I just feel it's less likely. I have only had cipro sans tobi perhaps once, probably the first time I cultured PA. ANyway, I'm wondering if the combination has helped keep the bug sensitive, or if I'm just lucky, or what. After a cipro/tobi course, I tend to freak out a bit for a while and exercise like a mad man for as long as I can. Usually I can go about 3-6 months before I need another cipro course. ALthough, usually I have a tobi course in between. Anyway, saveferris (Amy), if you have any articles in your archives that might help in my understanding of resistance, please point me to them! As I read these boards, sometimes it seems like docs might be getting lazy and just prescribing cipro without worry of resistance. Personally I think it shoudl alwauys be accompanied with another antibiotic. Just my amateur opinion.

 

[jdubbs]

I know you can pick up Cipro resistant bugs from the clinic, which honestly makes me nervous every time I go in. I have cultured PA for at least 10 years and so far I've been lucky enough to have sensitive bugs. Personally, my suspicion is that it takes a prolonged period of exposure to cipro before resistance becomes a serious problem. It's scary to think a single course of cipro would lead to resistance. I tend to think of resistance as a sort of gradual process. That said, I don't doubt there are instances of more sudden resistance. I just feel it's less likely. I have only had cipro sans tobi perhaps once, probably the first time I cultured PA. ANyway, I'm wondering if the combination has helped keep the bug sensitive, or if I'm just lucky, or what. After a cipro/tobi course, I tend to freak out a bit for a while and exercise like a mad man for as long as I can. Usually I can go about 3-6 months before I need another cipro course. ALthough, usually I have a tobi course in between. Anyway, saveferris (Amy), if you have any articles in your archives that might help in my understanding of resistance, please point me to them! As I read these boards, sometimes it seems like docs might be getting lazy and just prescribing cipro without worry of resistance. Personally I think it shoudl alwauys be accompanied with another antibiotic. Just my amateur opinion.

 

[saveferris2009]

Take a look at MRSA - MRSA used to be just Staph, right? now people can pick up MRSA without having ever cultured staph or ever taking an antibiotic for staph.

Same goes for any other bug. There is macrolide resistance Strep, aminoglycoside resistant PA.

A bug is a bug - regardless of whether you've had it before or not.

ANY BUG you come in contact with, you can pick up. And yes, a bug can mutate after just one exposure to an antibiotic.

If you want to speak to an expert, contact your local infectious disease specialist. I worked with them for 4 years, so I'm intimately familiar with how quickly bugs can mutate.

Being on two abx doesn't necessarily reduce resistance, but it can increase susceptibility. Think of it like this: you take two antibiotics, where one inhibits protein synthesis and one affects the cell wall. The bacteria that survives (because we know 100% of bacteria in CFer's are never destroyed) is able to ward off those two antibiotics - both cell wall and protein synthesis. So in other words, just because you used 2 abx at the same time, you didn't decrease the ability of the bacteria to be resistant.

Bacteria can share genes with each other, further promoting resistance without a single antibiotic exposure.

Hope that makes sense. It comes down to simple natural selection.

To put your mind at ease - the Danes use abx every 3 months, regardless of exacerbation status. This leads to higher resistance rates but slows down permanent lung damage. Which point to something every CFer needs to recognize - most often CFer's die of lung damage as opposed to pan resistance.

For example, not a very large # of CFer's with end stage CF or those applying for tx have pan-resistant bacteria. But almost all have severe lung damage.

 

[saveferris2009]

Take a look at MRSA - MRSA used to be just Staph, right? now people can pick up MRSA without having ever cultured staph or ever taking an antibiotic for staph.

Same goes for any other bug. There is macrolide resistance Strep, aminoglycoside resistant PA.

A bug is a bug - regardless of whether you've had it before or not.

ANY BUG you come in contact with, you can pick up. And yes, a bug can mutate after just one exposure to an antibiotic.

If you want to speak to an expert, contact your local infectious disease specialist. I worked with them for 4 years, so I'm intimately familiar with how quickly bugs can mutate.

Being on two abx doesn't necessarily reduce resistance, but it can increase susceptibility. Think of it like this: you take two antibiotics, where one inhibits protein synthesis and one affects the cell wall. The bacteria that survives (because we know 100% of bacteria in CFer's are never destroyed) is able to ward off those two antibiotics - both cell wall and protein synthesis. So in other words, just because you used 2 abx at the same time, you didn't decrease the ability of the bacteria to be resistant.

Bacteria can share genes with each other, further promoting resistance without a single antibiotic exposure.

Hope that makes sense. It comes down to simple natural selection.

To put your mind at ease - the Danes use abx every 3 months, regardless of exacerbation status. This leads to higher resistance rates but slows down permanent lung damage. Which point to something every CFer needs to recognize - most often CFer's die of lung damage as opposed to pan resistance.

For example, not a very large # of CFer's with end stage CF or those applying for tx have pan-resistant bacteria. But almost all have severe lung damage.

 

[saveferris2009]

Take a look at MRSA - MRSA used to be just Staph, right? now people can pick up MRSA without having ever cultured staph or ever taking an antibiotic for staph.

Same goes for any other bug. There is macrolide resistance Strep, aminoglycoside resistant PA.

A bug is a bug - regardless of whether you've had it before or not.

ANY BUG you come in contact with, you can pick up. And yes, a bug can mutate after just one exposure to an antibiotic.

If you want to speak to an expert, contact your local infectious disease specialist. I worked with them for 4 years, so I'm intimately familiar with how quickly bugs can mutate.

Being on two abx doesn't necessarily reduce resistance, but it can increase susceptibility. Think of it like this: you take two antibiotics, where one inhibits protein synthesis and one affects the cell wall. The bacteria that survives (because we know 100% of bacteria in CFer's are never destroyed) is able to ward off those two antibiotics - both cell wall and protein synthesis. So in other words, just because you used 2 abx at the same time, you didn't decrease the ability of the bacteria to be resistant.

Bacteria can share genes with each other, further promoting resistance without a single antibiotic exposure.

Hope that makes sense. It comes down to simple natural selection.

To put your mind at ease - the Danes use abx every 3 months, regardless of exacerbation status. This leads to higher resistance rates but slows down permanent lung damage. Which point to something every CFer needs to recognize - most often CFer's die of lung damage as opposed to pan resistance.

For example, not a very large # of CFer's with end stage CF or those applying for tx have pan-resistant bacteria. But almost all have severe lung damage.

 

[saveferris2009]

Take a look at MRSA - MRSA used to be just Staph, right? now people can pick up MRSA without having ever cultured staph or ever taking an antibiotic for staph.

Same goes for any other bug. There is macrolide resistance Strep, aminoglycoside resistant PA.

A bug is a bug - regardless of whether you've had it before or not.

ANY BUG you come in contact with, you can pick up. And yes, a bug can mutate after just one exposure to an antibiotic.

If you want to speak to an expert, contact your local infectious disease specialist. I worked with them for 4 years, so I'm intimately familiar with how quickly bugs can mutate.

Being on two abx doesn't necessarily reduce resistance, but it can increase susceptibility. Think of it like this: you take two antibiotics, where one inhibits protein synthesis and one affects the cell wall. The bacteria that survives (because we know 100% of bacteria in CFer's are never destroyed) is able to ward off those two antibiotics - both cell wall and protein synthesis. So in other words, just because you used 2 abx at the same time, you didn't decrease the ability of the bacteria to be resistant.

Bacteria can share genes with each other, further promoting resistance without a single antibiotic exposure.

Hope that makes sense. It comes down to simple natural selection.

To put your mind at ease - the Danes use abx every 3 months, regardless of exacerbation status. This leads to higher resistance rates but slows down permanent lung damage. Which point to something every CFer needs to recognize - most often CFer's die of lung damage as opposed to pan resistance.

For example, not a very large # of CFer's with end stage CF or those applying for tx have pan-resistant bacteria. But almost all have severe lung damage.

 

[saveferris2009]

Take a look at MRSA - MRSA used to be just Staph, right? now people can pick up MRSA without having ever cultured staph or ever taking an antibiotic for staph.
<br />
<br />Same goes for any other bug. There is macrolide resistance Strep, aminoglycoside resistant PA.
<br />
<br />A bug is a bug - regardless of whether you've had it before or not.
<br />
<br />ANY BUG you come in contact with, you can pick up. And yes, a bug can mutate after just one exposure to an antibiotic.
<br />
<br />If you want to speak to an expert, contact your local infectious disease specialist. I worked with them for 4 years, so I'm intimately familiar with how quickly bugs can mutate.
<br />
<br />Being on two abx doesn't necessarily reduce resistance, but it can increase susceptibility. Think of it like this: you take two antibiotics, where one inhibits protein synthesis and one affects the cell wall. The bacteria that survives (because we know 100% of bacteria in CFer's are never destroyed) is able to ward off those two antibiotics - both cell wall and protein synthesis. So in other words, just because you used 2 abx at the same time, you didn't decrease the ability of the bacteria to be resistant.
<br />
<br />Bacteria can share genes with each other, further promoting resistance without a single antibiotic exposure.
<br />
<br />Hope that makes sense. It comes down to simple natural selection.
<br />
<br />To put your mind at ease - the Danes use abx every 3 months, regardless of exacerbation status. This leads to higher resistance rates but slows down permanent lung damage. Which point to something every CFer needs to recognize - most often CFer's die of lung damage as opposed to pan resistance.
<br />
<br />For example, not a very large # of CFer's with end stage CF or those applying for tx have pan-resistant bacteria. But almost all have severe lung damage.
<br />
<br />
<br />
<br />

 

[coltsfan715]

I will say just to put this out there.
I took Cipro off and on growing up. I would take it eery few months for a few years then I would have a culture come back saying my psuedo was resistant then the docs would use something else for a few years. I never developed a resistance to other meds used to treat my Psuedo - I did have MRSA that was resistant to a lot of things but not the Psuedo.

Usually after a few years of not taking Psuedo I woud become sensitive to it again. So I had periods where I was resistant and periods where I was sensitive. Now post transplant I have only had to take antibiotics a few times and have taken Cipro maybe twice in the past few years and it clears up any sinus crud I tend to take it for so I assume the bugs are sensitive still.

Just wanted to put that out there kind of to say just because you develop resistance does not necessarily mean it is permanent. It can change -- at least it did for me growing up.

Linds

 

[coltsfan715]

I will say just to put this out there.
I took Cipro off and on growing up. I would take it eery few months for a few years then I would have a culture come back saying my psuedo was resistant then the docs would use something else for a few years. I never developed a resistance to other meds used to treat my Psuedo - I did have MRSA that was resistant to a lot of things but not the Psuedo.

Usually after a few years of not taking Psuedo I woud become sensitive to it again. So I had periods where I was resistant and periods where I was sensitive. Now post transplant I have only had to take antibiotics a few times and have taken Cipro maybe twice in the past few years and it clears up any sinus crud I tend to take it for so I assume the bugs are sensitive still.

Just wanted to put that out there kind of to say just because you develop resistance does not necessarily mean it is permanent. It can change -- at least it did for me growing up.

Linds

 

[coltsfan715]

I will say just to put this out there.
I took Cipro off and on growing up. I would take it eery few months for a few years then I would have a culture come back saying my psuedo was resistant then the docs would use something else for a few years. I never developed a resistance to other meds used to treat my Psuedo - I did have MRSA that was resistant to a lot of things but not the Psuedo.

Usually after a few years of not taking Psuedo I woud become sensitive to it again. So I had periods where I was resistant and periods where I was sensitive. Now post transplant I have only had to take antibiotics a few times and have taken Cipro maybe twice in the past few years and it clears up any sinus crud I tend to take it for so I assume the bugs are sensitive still.

Just wanted to put that out there kind of to say just because you develop resistance does not necessarily mean it is permanent. It can change -- at least it did for me growing up.

Linds

 

[coltsfan715]

I will say just to put this out there.
I took Cipro off and on growing up. I would take it eery few months for a few years then I would have a culture come back saying my psuedo was resistant then the docs would use something else for a few years. I never developed a resistance to other meds used to treat my Psuedo - I did have MRSA that was resistant to a lot of things but not the Psuedo.

Usually after a few years of not taking Psuedo I woud become sensitive to it again. So I had periods where I was resistant and periods where I was sensitive. Now post transplant I have only had to take antibiotics a few times and have taken Cipro maybe twice in the past few years and it clears up any sinus crud I tend to take it for so I assume the bugs are sensitive still.

Just wanted to put that out there kind of to say just because you develop resistance does not necessarily mean it is permanent. It can change -- at least it did for me growing up.

Linds

 

[coltsfan715]

I will say just to put this out there.
<br />I took Cipro off and on growing up. I would take it eery few months for a few years then I would have a culture come back saying my psuedo was resistant then the docs would use something else for a few years. I never developed a resistance to other meds used to treat my Psuedo - I did have MRSA that was resistant to a lot of things but not the Psuedo.
<br />
<br />Usually after a few years of not taking Psuedo I woud become sensitive to it again. So I had periods where I was resistant and periods where I was sensitive. Now post transplant I have only had to take antibiotics a few times and have taken Cipro maybe twice in the past few years and it clears up any sinus crud I tend to take it for so I assume the bugs are sensitive still.
<br />
<br />Just wanted to put that out there kind of to say just because you develop resistance does not necessarily mean it is permanent. It can change -- at least it did for me growing up.
<br />
<br />Linds