Sorry, I just had a few minutes to do a quick search, and realize now I was in teacher mode (to an advanced graduate level genetics class) when I gave my response. Please forgive me! Although I am a molecular microbiologist, I am not an expert, and from what I read last night even the experts do not agree on the importance of two normal NBDs. Let me see if I can explain, these NBD's are where the ATP binds and allows the opening and closing of the channel, thus allowing normal transport across the membrane. Because there are two of them, some researchers have found that as long as one of them is in tact, the ATP can bind, then gating (opening and closing of the channel) can occur as it normally does. So it appears as though it may not have any effect and is a benign mutation. HOWEVER, some of the literature I read disagrees with this. So little is really known and no one agrees on the importance of two in tact NBDs! But there is hope from what I have read! I apologize for not having a definitive yes or no answer, but your doctors or Steve will probably have the answer you are looking for! I hope you do not have to wait to long!!
