I agree with Mirilax. I have a lot of digestive problems and such from CF and my appetite decreases significantly if I don't use it somewhat consistently. I take it 2-3 times per week and it works great. If you have it bad now I would also say that using a saline laxative (magnesium citrate) would be good to just lush you out and get you ready. If I get bad (sometimes I forget to buy Mirilax and go like a month without) I will take the magnesium citrate on a Tuesday, on Thursday take Mirilax...and I'm back on schedule. I have weight issues so a loss in appetite is more a problem for me than not "being regular".