First night on PharmaNAC

Faust

New member
First off let me be the first to say that I have tried many different supplements, from a "Well that makes sense, let's me try that". I usually give a supplement 1-2 months of trial period, strictly abiding by the recommended dosage, or an elevated dosage due to CF malabsorption/trial and error and reviewing results. I used to take regular capsule NAC from NSI, totally unaware that the capsule stuff not only may be completely useless, but also possibly harm you due to it's exposure to air (inevitable with capsules).


So I was taking 1800 mg of NAC capsules every day, for maybe 6 months or longer. I noticed a very slight improvement in my mucous viscosity, but I mean very slight. I wondered why something with such a supposed very strong anti inflammatory trait would still leave me with obvious inflammation issues, even after such a while being on it. Thanks to Sak, now I know why. I was basically taking a an almost worthless placebo.


Well today I started taking my PharmaNAC (the airtight specially formulated one). After my first dose, I almost felt high, it was a very weird sensation. Not really lightheadedness, just an odd somewhat floating feeling...I suppose as close as I can describe it, it's slightly similar to coming out of surgery, when they put you under...Right before you are 100% back to normal mind wise.

I was at the gym lifting after my first dose, and I was actually laughing at how I felt. Second dose around 9pm did the same thing. Aside from the very slight loopiness, it felt (to me anyways) the internal non respiratory version of taking a breath of cold air, swooshing around inside me for a bit.

I know this sounds very weird, but i'm just trying to describe the sensation. After my second dose, I kid you not, I did feel better. Granted I am generally healthy now with the exception of some occasional bleeds, but I still cough up a good deal of goo. My lungs felt less constricted, and more "open".

You know how when you do hypertonic inhalation you almost immediately get a sputum expectorant response? Picture the same thing with this NAC, but instead of coughing stuff up, it was a sweeping "I feel better lung wise" sensation. I'm not sure if others will feel the same way, but I read Sak's blog, and she stated something similar. Very eary in the dosing, and notably feeling an immediate positive impact.


There was a somewhat similar experience when I was REALLY sick when I got back from the hospital, and I started OO under the tongue. I could immediately tell it was doing something in my body (killing bugs off), but OO took about two days of heavy dosing before I really started to feel it. This NAC was much quicker. Like if you have a real mean headache, and you take 4 high dose ibuprofen all at once.


I initially didn't want to pay the fairly steep cost of 3 doses a day for a months supply. I purchased enough for 2 doses a day, for a months supply. I'm going to bite the bullet and spend enough to stay at 3 a day. I read up some on Stanford's study on the stuff, and it's pretty amazing what they are finding out about the stuff, and what a profound change it's having in patients. The explanation of what exactly is happening makes perfect sense as well, and I will admit I wasn't 100% aware of exactly what was taking place. This probably won't be as corrective towards our disease as say insulin is for diabetics, but it seems that this holds promise to drastically slow down our inflammation problems, and overall pulmonary CF symptoms.


As Sak said, while this is still preliminary, and the jury isn't fully back in on this, all preliminary data suggest this is a must do regimen for every CF patient. I'm doing 3*900mg a day, because I heard the Stanford study was doing the same amount. I didn't want to try and evaluate something at a weakened dose and then think something didn't work.


If you are interested, you can search around the net for sources of the stuff, and I found a source for as low as 11 bucks for 20 tabs. Also, on a similar note, doing this NAC treatment + strict adherance to the vest and other nebs + good multivitamins and other strong antioxidant supplements + that new drug to help our ion transport coming out in 07, it's very possible that you can be very healthy, and live longer. As I said, it's extremely early, and i'm not putting my gold seal on this yet like I have OO, but I instantly felt better lung/body wise after just my first or second dose. I recommend all of us give it a shot.
 
M

moxie1

Guest
Sean,

How much glutathione are you doing now that you have increased your NAC dose?

The reason I am asking is that my GSH regimen recommends starting the day with 500mg of NAC as a GSH booster. If I take 1 PharmaNAC (900mg), is this too much with all of the glutathione too?

Thanks.
 

lilismom

Active member
Sean,
I'd like to start my daughter on NAC but haven't found anything about dosage for a child. She is about 42 lbs. Is there anything on the packaging that gives dosage amts?
Thanks
 

Faust

New member
@moxie: I am not on glutathione now, and haven't been for quite a long time. I tried the inhaled stuff for a month or two to give it a try, but to be honest, I didn't notice any improvement (i'm sure there were some, but it seemed like with the old brand of NAC, it was very slight). So now I am just on 900mg of PharmaNAC 3 times a day, evenly spaced out (I take it mostly in green tea, one when I wake up around noon, the other around 8pm, and the last dose before bed around 2-4am). To be honest with you, and I can only speak from what worked for me and how I feel now...The difference between how I felt on the glutathione and how I feel now on the new NAC is night and day. Of course you might be doing awesome on the glutathione, but if I were you, i'd save my money on the oral glutathione and try going for the NAC by itself. From what I understand, the preliminary CF trials so far on glutathione have showed it hardly has any benefit, as compared to the airtight NAC high doses...But again, I have no idea how you are doing now on glutathione alone, and what improvement you have seen.


@lilismom: I have no clue about the total doseage they used for juveniles/toddlers within the stanford NAC study. From what I have heard, and understand from reading, is that the stuff is extremely well tolerated, even at high doses. On the pamphlet insert from the packaging it even states you can do up to 7 doses a day, which would be 6,300mg of the stuff (a hell of a lot of NAC). I think I remember someone on here telling me that the doseage was the same for everyone on the trial, so i'm assuming that also meant they targeted younger patients as well. I heard the doseage for patients on the trial was all 2700mg a day (900mg 3 times a day) universally.


Of course don't take my word on that because i don't know 100% I'm sure for someone very young (like your 3 year old), the package dosing of 2 a day @ 900mg would be sufficient (because the package didn't say anything about changing doseage for children). I'm sure you could google up their website and call them and ask.


Here is their website: <a target=_blank class=ftalternatingbarlinklarge href="http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp
">http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp
</a>

If you plan on ordering the stuff and trying it out, I wouldn't order through them though, they are pricey (if I remember right and they do sell it direct). As I said, i was able to find a source for 11 bucks a package.
 

Faust

New member
BTW I give all credit regarding this to Sak...She informed me about it, i'm just relating my preliminary experiences with it and passing the word on. As Sak has said before, from what they are finding in the Stanford study, it's showing more and more that relative high doses of a quality NAC supplement (kept away from air) is having extremely good impacts on our health. I woke up this morning feeling extremely good.


Here is a copy and paste regarding their product, and a wikipedia link regarding NAC.

<a target=_blank class=ftalternatingbarlinklarge href="http://en.wikipedia.org/wiki/N-acetylcysteine
">http://en.wikipedia.org/wiki/N-acetylcysteine
</a>



Products » General Health » PharmaNACTM

PharmaNACTM - 900mg effervescent tablets

Pure N-acetylcysteine (NAC) - Wildberry Flavour


Supports a healthy immune system and good respiratory function*

N-acetylcysteine or "NAC" for short, is a derivative of the amino acid L-cysteine, which is a essential precursor used by the body to produce glutathione. Glutathione is a extremely important and powerful antioxidant produced by the body to help protect against free radical damage, and is a critical factor in supporting a healthy immune system.*

PharmaNAC:

* Certified European GMP grade NAC
* Effective way to help boost glutathione levels.*
* Effervescent, quick-dissolving tablets allow NAC to enter cells readily ensuring rapid absorption.
* Quality controlled according to pharmaceutical guidelines.
* Compliant to the standards of European Pharmacopoeia and United States Pharmacopoeia.
* High quality, extremely stable, great tasting and odorless NAC.
* Individually wrapped tablets in a special 4-layer (paper/plastic/foil plastic) air-tight material to prevent moisture and air from destabilizing and degrading the NAC; a major problem with most other over the counter (OTC) NAC products bottled in capsule form.

PharmaNAC delivers ThiolexTM, BioAdvantex Pharma's high-quality and trusted preparation of pure N-acetylcysteine (PATENT PROTECTED. Exclusive licensee of US patent # 6,566,401). Thiolex brand NAC has been trusted and used by various members of the academic community in clinical studies examining the role of NAC in supporting a healthy immune system and good respiratory function.*

PharmaNAC is an advanced NAC delivery system and the only effervescent preparation of its kind available in North America. The quality of PharmaNAC is controlled according to pharmaceutical guidelines. Thiolex, the brand of N-acetylcysteine (NAC) used in PharmaNAC, is certified compliant to the standards of European Phamacopoeia and United States Phamacopoeia (USP).

Quality Alert:

NAC is an antioxidant that must be processed in an extremely dry environment with extremely limited exposure to air. If it becomes oxidized to any degree, then it becomes destabilized and therapeutically ineffective. Unfortunately, some OTC NAC supplements sold on the market today are not manufactured under such strictly controlled environments due to the enormous associated control costs. As a result, these products often have little or no active NAC in them, despite labeling to the contrary.

This is precisely why BioAdvantex takes great care in diligently manufacturing PharmaNAC according to strict pharmaceutical standards. Special care is required to ensure that the components of each PharmaNAC tablet do not react during manufacture or within the compressed tablet following manufacture. In fact, each PharmaNAC tablet is individually wrapped in a special 4-layer (paper/plastic/foil plastic) air-tight material to prevent moisture and air from destabilizing and degrading the NAC (unlike other NAC products that loosely package numerous quantities of NAC capsules in a plastic bottle openly exposed to air). Our European GMP-compliant manufacturing process secures consistent quality, content uniformity, and stability in each and every 900mg effervescent tablet.

Advantages of quick dissolving effervescent tablets versus traditional pills, capsules, and tablets. Click here.


Supplement Facts
Serving Size: 1 effervescent tablet


Amount per Tablet % Daily Value

Sodium
200 mg

8 %
N-acetylcysteine (Thiolextm)
900 mg

**

**Daily value not established


Other Ingredients: Citric acid, sodium bicarbonate, sodium carbonate, mannitol, wildberry flavour, acesulfame potassium, trisodium dicitrate.

Directions: Dissolve one tablet in water, fruit juice, or carbonated beverage twice daily, or at the advice of your physician. Do not consume with milk or milk products. May be taken with or without food.

Quantity: Each box of PharmaNAC contains 20 - 900mg effervescent tablets.
 

lilismom

Active member
thanks I'll try to contact them. I ordered the dvd's from the Stanford info day and that is what got me so interested in NAC.
 

Faust

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>lilismom</b></i>

thanks I'll try to contact them. I ordered the dvd's from the Stanford info day and that is what got me so interested in NAC.</end quote></div>



I need to get off my ass and order the DVD as well. I have been hemorrhaging money recently though
 

Scarlett81

New member
oh I want to start it so bad but I don't anything about its safety during breastfeeding! does anyone know??
thanks for the info by the way.
 

Faust

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Scarlett81</b></i>

oh I want to start it so bad but I don't anything about its safety during breastfeeding! does anyone know??

thanks for the info by the way.</end quote></div>


Yeah the breast feeding thing is a giant question mark/caution flag. I'd probably wait till you are done with that before taking it. But you could call the company and ask them if it transfers through breast milk (it probably does), and if so, what are the potential risks for a newborn. I'm curious what the answers may be.
 

Ender

New member
Thanks for the update man. I'm gonna get my hands on this as soon as possible. Sounds pretty damn promising.
 

jfarel

New member
I don't mean to be a "downer" or anything, because I still believe this stuff will work and is working, but I felt better the first two or three days after taking the PharmaNAC and I assumed it was some kind of placebo effect. After about three or four days pretty close to how I normally feel. Granted my FEV1 is way lower than Sak and Faust, so it may take longer to have an effect on me, but I just thought I would update everyone on how I am doing as well. I was actually going to post this if Faust had not, because I wanted to know how everyone else was doing that was also taking the PharmaNAC. Again, I do think it is probably working, I'm just not feeling real great right now. I'd be curious to know how Sak is doing with the Pharma grade NAC as well. I'm also taking 2,800 mg a day. I just put mine in water.

I stopped the glutathion about the same time as I started the NAC. Ironically, gluatathione had a similar effect when I started taking it. My problem with the glut. was that it caused me to feel bloated and I had a difficicult time having bowel movements. I was unable to get bowels straightened out until I stopped it. I'm considering going back on the glutathione since it did give me more energy, but I will take it at 500mg a day instead, to try and prevent the bowel issues.
 

my65roses4me

New member
night on PharmaNAC

How can I get a copy of the Stanford DVD? I would love to get so I can hear what they said. Anyone have an idea where I can order a copy?
 

lilismom

Active member
go to cfri.org to order a copy. You can order the whole 8 disc set from the info day or just any one of the discs for $3.
 

kayleesgrandma

New member
You can also go to the top of th adult forum page and type in Stanford DVD, and you'll get pages of discussion about NAC AND GHS. Amy has a section in her blog unde medicine if you want to read more.
 

DanielleB

New member
I've heard great things about PharmaNAC, especially in relation to its safety and high quality. Many NAC products are at risk of oxidizing while in production, but BioAdvantex uses a special preparation process that ensures the NAC will be pure and protected from oxidation risk.
Also, I saw on their facebook page that they are having a two for one deal right now. I'm gonna try it out, especially since you can get a whole box free!
 

AnD

New member
Oh wow, DanielleB, THANKS!! I was getting ready to reorder, and this is GREAT info!! <img src="i/expressions/face-icon-small-smile.gif" border="0">
 

AnD

New member
Oh wow, DanielleB, THANKS!! I was getting ready to reorder, and this is GREAT info!! <img src="i/expressions/face-icon-small-smile.gif" border="0">
 

MissMe

New member
Hi! I'm a bit confused here.. The NAC you're discussing isn't it simply Acetylcystein (or Mucomust)?!? I've been on that for 30 years now, 200mgx3 effervescent tablets a day and in inhalation. (I live in Sweden ). It simply makes the mucus get looser so that we can remove it from the lungs and it is sold in every pharmacy in Europe. Or are you talking about some other medication?
 
Top