The biggest thing is the planning and discussion beforehand, IMHO. You and your husband will have to look at the whole, big picture, and deal with things like "Are you willing and capable of raising a child by yourself?" for both him and you. Unfortunately, things can happen to healthy people too. Do you have a good support system? That is important for any parent, and especially for us, IMHO again.
The time, the money, how far you are willing to go to have a biological child (best to have looked at this before you get in the emotional middle of it if there are issues that come up).
Basically, the "gameplan" needs to be hashed out to a rough draft, a framework for you to build on, so there are less surprises.
My biggest issue was the "after the baby was born" of getting enough rest. A good support system (friends and relatives who can come pretty much at the drop of a hat) was crucial for me. The first few months were utterly exhausting (wonderful, but exhausting <img src="i/expressions/face-icon-small-wink.gif" border="0"> ), and I ended up with home IVs in the first 6 months. I also had some misdiagnosed underlying stomach issues (chronic pancreatitis, apparently, and H. pylori) that added to my problems, that aren't the norm.
I stay home too (and pretty much, other than a couple of part time jobs early in our marriage) always have (I'm an artist, or was, lol). I really think that that has helped my health out considerably. My last FEV1 was actually up from 5 years ago, by 9% (I've been sick, so I'm kinda dreading my next pft's...*sigh* <img src="i/expressions/face-icon-small-wink.gif" border="0"> ).
My daughter doesn't <i>go</i> to preschool (we are trying homeschool, and so far liking it. I also have [noncf] friends who homeschool). She didn't go to the church nursery, either (she was a preemie).
She does go to Sunday School now and Awanas (she's four). I do get a few more colds that before, but not too bad. It also helps that her 2 main playmates, it turned out, have asthma, so their parents understand the "no sick playdates" as they already go by that for themselves, and that helps me stay healthy <img src="i/expressions/face-icon-small-smile.gif" border="0"> .
I have actually become more proactive and compliant with my meds and treatments since having my daughter. I know that taking care of myself is the best thing I can do for both me and my family. The healthier I am, the more time (both short term and long term) I will have to spend with my daughter while she's young, and my husband when we're old <img src="i/expressions/face-icon-small-wink.gif" border="0"> .
That's where we are now. I hope that helped you some.