GSH/NAC

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dasjsmum

New member
Amy

Do you take 600mg once or twice daily? Do you know of a mg to kg/lb ratio (for NAC)? I'm trying to get some NAC for Sam, but have had him on GSH for a few months...it's hard to know whether it is making a difference or not. Where did you get your NAC in Europe? Do they post overseas?
As far as the GSH goes, I get it from Theranaturals which also sells the buffered type for inhalation. I havent been nebulising GSH for Sam at present, only on oral.
 
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NoExcuses

New member
I started off taking 600mg QD for three months to see how I tolerated. I tolerated it fine so I went up to 600mg BID. Eventually I'll probably go up to 600mg TID.

I have been asked many times about kid's dosing, but I have no idea, sorry.

In terms of where I got my NAC in Europe, as I said, my boyfriend brought it back for me. His parents are both physicians in Europe so access to Rx's are simple.
 
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NoExcuses

New member
I started off taking 600mg QD for three months to see how I tolerated. I tolerated it fine so I went up to 600mg BID. Eventually I'll probably go up to 600mg TID.

I have been asked many times about kid's dosing, but I have no idea, sorry.

In terms of where I got my NAC in Europe, as I said, my boyfriend brought it back for me. His parents are both physicians in Europe so access to Rx's are simple.
 
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NoExcuses

New member
I started off taking 600mg QD for three months to see how I tolerated. I tolerated it fine so I went up to 600mg BID. Eventually I'll probably go up to 600mg TID.

I have been asked many times about kid's dosing, but I have no idea, sorry.

In terms of where I got my NAC in Europe, as I said, my boyfriend brought it back for me. His parents are both physicians in Europe so access to Rx's are simple.
 
S

sue35

New member
So is the oral NAC a pill you can swallow or just dissolve in a drink like Amy has? Also, are there any places here that are reputable where you know you are getting the right NAC? I would like to start it over GSH but would like to know I am getting the right stuff. I have no way of getting it overseas. Thanks!
 
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sue35

New member
So is the oral NAC a pill you can swallow or just dissolve in a drink like Amy has? Also, are there any places here that are reputable where you know you are getting the right NAC? I would like to start it over GSH but would like to know I am getting the right stuff. I have no way of getting it overseas. Thanks!
 
S

sue35

New member
So is the oral NAC a pill you can swallow or just dissolve in a drink like Amy has? Also, are there any places here that are reputable where you know you are getting the right NAC? I would like to start it over GSH but would like to know I am getting the right stuff. I have no way of getting it overseas. Thanks!
 
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NoExcuses

New member
if you read the links I posted above, the threads include a link to the company that Moss used in his Stanford study.

And they ship to the US.
 
N

NoExcuses

New member
if you read the links I posted above, the threads include a link to the company that Moss used in his Stanford study.

And they ship to the US.
 
N

NoExcuses

New member
if you read the links I posted above, the threads include a link to the company that Moss used in his Stanford study.

And they ship to the US.
 
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NoExcuses

New member
<a target=_blank class=ftalternatingbarlinklarge href="http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp">http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp</a>
 
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NoExcuses

New member
<a target=_blank class=ftalternatingbarlinklarge href="http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp">http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp</a>
 
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NoExcuses

New member
<a target=_blank class=ftalternatingbarlinklarge href="http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp">http://www.bioadvantex.com/us/02_ghealth_pharmanac.asp</a>
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>sakasuka</b></i>

Kiel I totaly see what you're saying about the extracellular environment. What you're saying makes sense.



Help me understand how Moss at Stanford got these results then when giving oral NAC?



"in 18 CF patients with stable disease, blood neutrophils were readily deficient in the pivotal antioxidant glutathione (P = 0.003, compared with 9 healthy controls). In a phase 1 study, <b> this deficiency was improved (P = 0.025) </b> by the glutathione prodrug N-acetylcysteine, given orally in high doses (0.6 to 1.0 g three times daily, for 4 weeks). This treatment was safe and markedly <b> decreased sputum elastase activity (P = 0.006), </b> the strongest predictor of CF pulmonary function. Consistently, <b>neutrophil burden in CF airways was decreased upon treatment (P = 0.003), </b> as was the number of airway neutrophils actively releasing elastase-rich granules (P = 0.005), as measured by flow cytometry. "



Placebo effect?????</end quote></div>

I think gsh is critical in a cells function both internally and externally. So if neutrophils were deficient in GSH and you were to increase it, it would definitely help the overall state of these cells and help them function the way they are suppose to.

However, the problem, i think, is that because of intrinsic defects in GSH transport to the outside of cells OR a gradual depletion of extracellular GSH through sustained infection, that when these white blood cells are releasing Reactive Oxygen Species (ROS...free radicals) to kill invading cells, we don't have enough of the main anti oxidant around to soak up all the harmful crap our immune system is releasing on us.

I think that is a huge reason as well that we are healthier when we are younger. Our anti oxidant stores are higher, and i suppose our nutritional states as well. However, as we get older and live longer with this stress on our body, is starts depleting it of resources that it needs to defend itself. If we don't repelenish the GSH and the vitamins and the amino acids that our immune system needs (it isn't meant for a prolonged period of activation), then it messes us up, basically.

I hope this made sense. It's 9 am and i just got home from my overnight shift...
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>sakasuka</b></i>

Kiel I totaly see what you're saying about the extracellular environment. What you're saying makes sense.



Help me understand how Moss at Stanford got these results then when giving oral NAC?



"in 18 CF patients with stable disease, blood neutrophils were readily deficient in the pivotal antioxidant glutathione (P = 0.003, compared with 9 healthy controls). In a phase 1 study, <b> this deficiency was improved (P = 0.025) </b> by the glutathione prodrug N-acetylcysteine, given orally in high doses (0.6 to 1.0 g three times daily, for 4 weeks). This treatment was safe and markedly <b> decreased sputum elastase activity (P = 0.006), </b> the strongest predictor of CF pulmonary function. Consistently, <b>neutrophil burden in CF airways was decreased upon treatment (P = 0.003), </b> as was the number of airway neutrophils actively releasing elastase-rich granules (P = 0.005), as measured by flow cytometry. "



Placebo effect?????</end quote></div>

I think gsh is critical in a cells function both internally and externally. So if neutrophils were deficient in GSH and you were to increase it, it would definitely help the overall state of these cells and help them function the way they are suppose to.

However, the problem, i think, is that because of intrinsic defects in GSH transport to the outside of cells OR a gradual depletion of extracellular GSH through sustained infection, that when these white blood cells are releasing Reactive Oxygen Species (ROS...free radicals) to kill invading cells, we don't have enough of the main anti oxidant around to soak up all the harmful crap our immune system is releasing on us.

I think that is a huge reason as well that we are healthier when we are younger. Our anti oxidant stores are higher, and i suppose our nutritional states as well. However, as we get older and live longer with this stress on our body, is starts depleting it of resources that it needs to defend itself. If we don't repelenish the GSH and the vitamins and the amino acids that our immune system needs (it isn't meant for a prolonged period of activation), then it messes us up, basically.

I hope this made sense. It's 9 am and i just got home from my overnight shift...
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>sakasuka</b></i>

Kiel I totaly see what you're saying about the extracellular environment. What you're saying makes sense.



Help me understand how Moss at Stanford got these results then when giving oral NAC?



"in 18 CF patients with stable disease, blood neutrophils were readily deficient in the pivotal antioxidant glutathione (P = 0.003, compared with 9 healthy controls). In a phase 1 study, <b> this deficiency was improved (P = 0.025) </b> by the glutathione prodrug N-acetylcysteine, given orally in high doses (0.6 to 1.0 g three times daily, for 4 weeks). This treatment was safe and markedly <b> decreased sputum elastase activity (P = 0.006), </b> the strongest predictor of CF pulmonary function. Consistently, <b>neutrophil burden in CF airways was decreased upon treatment (P = 0.003), </b> as was the number of airway neutrophils actively releasing elastase-rich granules (P = 0.005), as measured by flow cytometry. "



Placebo effect?????</end quote></div>

I think gsh is critical in a cells function both internally and externally. So if neutrophils were deficient in GSH and you were to increase it, it would definitely help the overall state of these cells and help them function the way they are suppose to.

However, the problem, i think, is that because of intrinsic defects in GSH transport to the outside of cells OR a gradual depletion of extracellular GSH through sustained infection, that when these white blood cells are releasing Reactive Oxygen Species (ROS...free radicals) to kill invading cells, we don't have enough of the main anti oxidant around to soak up all the harmful crap our immune system is releasing on us.

I think that is a huge reason as well that we are healthier when we are younger. Our anti oxidant stores are higher, and i suppose our nutritional states as well. However, as we get older and live longer with this stress on our body, is starts depleting it of resources that it needs to defend itself. If we don't repelenish the GSH and the vitamins and the amino acids that our immune system needs (it isn't meant for a prolonged period of activation), then it messes us up, basically.

I hope this made sense. It's 9 am and i just got home from my overnight shift...
 
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NoExcuses

New member
I figured there is no way I could see a difference in my lungs after two doses of Euro NAC.....

If someone else posted this, I would dismiss it immediately.....

But I have never had an easier time exercising on my eliptical as I did this morning. Granted, I have been exercising consistently for 2.5 weeks now. So I guess all of a sudden my endurance could have gone up.

But man did I feel different exercising this morning. Really different.

At worst, this is a huge endorsement for excercising and lung function. At best, this NAC stuff works quickly.

I'm still skeptical of the NAC stuff working quickly.

And I'm a strong believer in the placebo effect. So that could be it as well.

I'm curious to hear from others who order from Moss' company in Canada or Europeans who take Euro NAC. Let me know.
 
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