Patricia12569
New member
Thank you Alyssa. The info you gave me has been a big help!
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an alternative browser.
You should upgrade or use an alternative browser.
Help please!!!!!
- Thread starter Patricia12569
- Start date
Patricia12569
New member
Thank you Alyssa. The info you gave me has been a big help!
Patricia12569
New member
Thank you Alyssa. The info you gave me has been a big help!
Patricia12569
New member
Thank you Alyssa. The info you gave me has been a big help!
Patricia12569
New member
Thank you Alyssa. The info you gave me has been a big help!
Welcom to the site. Below, I've listed some info that Emily65Roses gave me a while back when someone had a question about mutations. Also, you can do a search and read all of the discussions here about them. Another good source of information is LightNlife's blog. She has links to all sorts of articles and information. There are a lot of well informed members here and I know they will be happy to explain things to you.
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
Welcom to the site. Below, I've listed some info that Emily65Roses gave me a while back when someone had a question about mutations. Also, you can do a search and read all of the discussions here about them. Another good source of information is LightNlife's blog. She has links to all sorts of articles and information. There are a lot of well informed members here and I know they will be happy to explain things to you.
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
Welcom to the site. Below, I've listed some info that Emily65Roses gave me a while back when someone had a question about mutations. Also, you can do a search and read all of the discussions here about them. Another good source of information is LightNlife's blog. She has links to all sorts of articles and information. There are a lot of well informed members here and I know they will be happy to explain things to you.
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
Welcom to the site. Below, I've listed some info that Emily65Roses gave me a while back when someone had a question about mutations. Also, you can do a search and read all of the discussions here about them. Another good source of information is LightNlife's blog. She has links to all sorts of articles and information. There are a lot of well informed members here and I know they will be happy to explain things to you.
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
Welcom to the site. Below, I've listed some info that Emily65Roses gave me a while back when someone had a question about mutations. Also, you can do a search and read all of the discussions here about them. Another good source of information is LightNlife's blog. She has links to all sorts of articles and information. There are a lot of well informed members here and I know they will be happy to explain things to you.
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses
I'm sorry you are faced with this disease. This site is full of support and information. I firmly believe that knowledge is power and there is much knowledge to be obtained here. I wish you and your family the best.
Stacey
Class I: Defective protein production with premature termination of CFTR production. Class 1 mutations produce few or no functioning CFTR chloride channels
Class II: Defective trafficking of CFTR so that it does not reach the apical surface membrane where it is intended to function
Class III: Defective regulation of CFTR even though it is able to reach the apical cell surface
Class IV: CFTR reaches the apical surface but conduction through the channel is defective
Class V: Associated with reduced synthesis of functional CFTR
(Source: <a target=_blank class=ftalternatingbarlinklarge href="http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm">http://www.cysticfibrosismedic...CFdocs/CFText/gene.htm</a> )
Everything in this following paragraph is simply my interpretation of that information above, in easier to understand terms. I may be a little off in explaining them, so don't quote me. If anyone understands it better, feel free to correct me where necessary.
The CFTR stands for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It's basically a channel between cells that doesn't work right in CFers. Class I, in lamen's terms, as it says above, produce no or few CFTRs. Class II has CFTRs but they don't travel to the right places, Class III has CFTRs, and they get to the right place, they're just not 100% functional. Class IV the CFTRs are there, they get to the right place, and they work well, but the channel creates a problem. And Class V has CFTRs that function correctly, just not all the time (basically, they have some working ones and some not).
As you can see, the descriptions of the defect get milder as the Class number gets higher. You go from "no CFTRs" in a Class I, to "sometimes they don't work" in a Class V. Big difference.
-------------------------
Emily. 23 w/CF.
*Dating Mike since 8-11-03*
*Getting married on 4-9-10*
Edited: 06/15/2007 at 03:21 PM by Emily65Roses