Honestly.....

[NoExcuses]

Sonia the sad thing is the in this legal environment, there is no way tobramycin would be approved. In fact there would probably be class action lawsuits against it as well.

I'm just hoping you and others will read with a critical and skeptical eye about what truly is going on. You can have a class action lawsuit against any med because they all have side effects.

And quite frankly we all need to be worried at which the frequency the FDA is not allowing new drugs to reach the market. I realize safety is key - but if the pendulum swings too far, we will be without many medications that can help not only CFers but with many other health issues.

I would prefer patients decide risks vs. benefits with their doctors than the FDA to not approve any medication with a side effect. It's horrifying.

 

[NoExcuses]

Sonia the sad thing is the in this legal environment, there is no way tobramycin would be approved. In fact there would probably be class action lawsuits against it as well.

I'm just hoping you and others will read with a critical and skeptical eye about what truly is going on. You can have a class action lawsuit against any med because they all have side effects.

And quite frankly we all need to be worried at which the frequency the FDA is not allowing new drugs to reach the market. I realize safety is key - but if the pendulum swings too far, we will be without many medications that can help not only CFers but with many other health issues.

I would prefer patients decide risks vs. benefits with their doctors than the FDA to not approve any medication with a side effect. It's horrifying.

 

[NoExcuses]

Sonia the sad thing is the in this legal environment, there is no way tobramycin would be approved. In fact there would probably be class action lawsuits against it as well.

I'm just hoping you and others will read with a critical and skeptical eye about what truly is going on. You can have a class action lawsuit against any med because they all have side effects.

And quite frankly we all need to be worried at which the frequency the FDA is not allowing new drugs to reach the market. I realize safety is key - but if the pendulum swings too far, we will be without many medications that can help not only CFers but with many other health issues.

I would prefer patients decide risks vs. benefits with their doctors than the FDA to not approve any medication with a side effect. It's horrifying.

 

[NoExcuses]

Sonia the sad thing is the in this legal environment, there is no way tobramycin would be approved. In fact there would probably be class action lawsuits against it as well.

I'm just hoping you and others will read with a critical and skeptical eye about what truly is going on. You can have a class action lawsuit against any med because they all have side effects.

And quite frankly we all need to be worried at which the frequency the FDA is not allowing new drugs to reach the market. I realize safety is key - but if the pendulum swings too far, we will be without many medications that can help not only CFers but with many other health issues.

I would prefer patients decide risks vs. benefits with their doctors than the FDA to not approve any medication with a side effect. It's horrifying.

 

[NoExcuses]

Sonia the sad thing is the in this legal environment, there is no way tobramycin would be approved. In fact there would probably be class action lawsuits against it as well.
<br />
<br />I'm just hoping you and others will read with a critical and skeptical eye about what truly is going on. You can have a class action lawsuit against any med because they all have side effects.
<br />
<br />And quite frankly we all need to be worried at which the frequency the FDA is not allowing new drugs to reach the market. I realize safety is key - but if the pendulum swings too far, we will be without many medications that can help not only CFers but with many other health issues.
<br />
<br />I would prefer patients decide risks vs. benefits with their doctors than the FDA to not approve any medication with a side effect. It's horrifying.

 

[krisgabes]

unfortunately there are a lot of those IV meds that list that as a "side effect". amikacin does too. i agree with NoExcuses to keep these things all in perspective.

 

[krisgabes]

unfortunately there are a lot of those IV meds that list that as a "side effect". amikacin does too. i agree with NoExcuses to keep these things all in perspective.

 

[krisgabes]

unfortunately there are a lot of those IV meds that list that as a "side effect". amikacin does too. i agree with NoExcuses to keep these things all in perspective.

 

[krisgabes]

unfortunately there are a lot of those IV meds that list that as a "side effect". amikacin does too. i agree with NoExcuses to keep these things all in perspective.

 

[krisgabes]

unfortunately there are a lot of those IV meds that list that as a "side effect". amikacin does too. i agree with NoExcuses to keep these things all in perspective.

 

[ladybug]

I agree there are MANY bad, terrible and scary side effects to ALL the meds we take. I am not arguing that. I also agree it take the FDA WAYYYY too long to get us meds we could use due to "red tape", however this is what worries me:

<b>"The article in the May 2007 issue of The Lancet Infectious Diseases describes <u>a higher all-cause mortality in patients treated with cefepime compared to other ? - lactams</u>. Overall, the all-cause mortality was higher with cefepime than other ?-lactams (risk ratio [RR] 1·26 [95% CI 1·08 - 1·49]) and for the subgroup of patients with febrile neutropenia (RR 1·42 [95% CI 1·09 - 1·84])."</b>


There obviously are unreasonably higher mortality rates that they think MAY be attributable to cefepime than other B-lactams (as the article states). I agree to read carefully and not draw unwarranted conclusions, which I have tried not to do, however, if you read the article in its entirety, you will see that this is different than just the usual "side effects" or "risks" involved with any drug.

Either way, I know its important to discuss things like this with the docs and I do plan on doing so this friday at my appt. I am just very pro-active and like to know what I'm putting in my veins (as we all are) and if there are alternatives to something that may or may not cause death (and is under investigation by the FDA for said complications), I think I'd rather my docs choose those until more information can be obtained.

I have argued in the past when my doctor wanted to put me on chloramphenicol and I did extensive online research that found that its use for CF should be a "last resort" as it has been shown to cause cancer, etc. more than other treatments for CF. Therefore, he did not prescribe it and found an alternative with "safer" consequences. I did very well on the med he used instead and felt a TON better about what I was putting into my body. I'm sure I would have worried the entire treatment had I read those studies and still used it when many other meds were still viable choices. That is all I'm referring to.

I appreciate ya'll trying to put my mind at ease about this though. I know sometimes I need that! <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I agree there are MANY bad, terrible and scary side effects to ALL the meds we take. I am not arguing that. I also agree it take the FDA WAYYYY too long to get us meds we could use due to "red tape", however this is what worries me:

<b>"The article in the May 2007 issue of The Lancet Infectious Diseases describes <u>a higher all-cause mortality in patients treated with cefepime compared to other ? - lactams</u>. Overall, the all-cause mortality was higher with cefepime than other ?-lactams (risk ratio [RR] 1·26 [95% CI 1·08 - 1·49]) and for the subgroup of patients with febrile neutropenia (RR 1·42 [95% CI 1·09 - 1·84])."</b>


There obviously are unreasonably higher mortality rates that they think MAY be attributable to cefepime than other B-lactams (as the article states). I agree to read carefully and not draw unwarranted conclusions, which I have tried not to do, however, if you read the article in its entirety, you will see that this is different than just the usual "side effects" or "risks" involved with any drug.

Either way, I know its important to discuss things like this with the docs and I do plan on doing so this friday at my appt. I am just very pro-active and like to know what I'm putting in my veins (as we all are) and if there are alternatives to something that may or may not cause death (and is under investigation by the FDA for said complications), I think I'd rather my docs choose those until more information can be obtained.

I have argued in the past when my doctor wanted to put me on chloramphenicol and I did extensive online research that found that its use for CF should be a "last resort" as it has been shown to cause cancer, etc. more than other treatments for CF. Therefore, he did not prescribe it and found an alternative with "safer" consequences. I did very well on the med he used instead and felt a TON better about what I was putting into my body. I'm sure I would have worried the entire treatment had I read those studies and still used it when many other meds were still viable choices. That is all I'm referring to.

I appreciate ya'll trying to put my mind at ease about this though. I know sometimes I need that! <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I agree there are MANY bad, terrible and scary side effects to ALL the meds we take. I am not arguing that. I also agree it take the FDA WAYYYY too long to get us meds we could use due to "red tape", however this is what worries me:

<b>"The article in the May 2007 issue of The Lancet Infectious Diseases describes <u>a higher all-cause mortality in patients treated with cefepime compared to other ? - lactams</u>. Overall, the all-cause mortality was higher with cefepime than other ?-lactams (risk ratio [RR] 1·26 [95% CI 1·08 - 1·49]) and for the subgroup of patients with febrile neutropenia (RR 1·42 [95% CI 1·09 - 1·84])."</b>


There obviously are unreasonably higher mortality rates that they think MAY be attributable to cefepime than other B-lactams (as the article states). I agree to read carefully and not draw unwarranted conclusions, which I have tried not to do, however, if you read the article in its entirety, you will see that this is different than just the usual "side effects" or "risks" involved with any drug.

Either way, I know its important to discuss things like this with the docs and I do plan on doing so this friday at my appt. I am just very pro-active and like to know what I'm putting in my veins (as we all are) and if there are alternatives to something that may or may not cause death (and is under investigation by the FDA for said complications), I think I'd rather my docs choose those until more information can be obtained.

I have argued in the past when my doctor wanted to put me on chloramphenicol and I did extensive online research that found that its use for CF should be a "last resort" as it has been shown to cause cancer, etc. more than other treatments for CF. Therefore, he did not prescribe it and found an alternative with "safer" consequences. I did very well on the med he used instead and felt a TON better about what I was putting into my body. I'm sure I would have worried the entire treatment had I read those studies and still used it when many other meds were still viable choices. That is all I'm referring to.

I appreciate ya'll trying to put my mind at ease about this though. I know sometimes I need that! <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I agree there are MANY bad, terrible and scary side effects to ALL the meds we take. I am not arguing that. I also agree it take the FDA WAYYYY too long to get us meds we could use due to "red tape", however this is what worries me:

<b>"The article in the May 2007 issue of The Lancet Infectious Diseases describes <u>a higher all-cause mortality in patients treated with cefepime compared to other ? - lactams</u>. Overall, the all-cause mortality was higher with cefepime than other ?-lactams (risk ratio [RR] 1·26 [95% CI 1·08 - 1·49]) and for the subgroup of patients with febrile neutropenia (RR 1·42 [95% CI 1·09 - 1·84])."</b>


There obviously are unreasonably higher mortality rates that they think MAY be attributable to cefepime than other B-lactams (as the article states). I agree to read carefully and not draw unwarranted conclusions, which I have tried not to do, however, if you read the article in its entirety, you will see that this is different than just the usual "side effects" or "risks" involved with any drug.

Either way, I know its important to discuss things like this with the docs and I do plan on doing so this friday at my appt. I am just very pro-active and like to know what I'm putting in my veins (as we all are) and if there are alternatives to something that may or may not cause death (and is under investigation by the FDA for said complications), I think I'd rather my docs choose those until more information can be obtained.

I have argued in the past when my doctor wanted to put me on chloramphenicol and I did extensive online research that found that its use for CF should be a "last resort" as it has been shown to cause cancer, etc. more than other treatments for CF. Therefore, he did not prescribe it and found an alternative with "safer" consequences. I did very well on the med he used instead and felt a TON better about what I was putting into my body. I'm sure I would have worried the entire treatment had I read those studies and still used it when many other meds were still viable choices. That is all I'm referring to.

I appreciate ya'll trying to put my mind at ease about this though. I know sometimes I need that! <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I agree there are MANY bad, terrible and scary side effects to ALL the meds we take. I am not arguing that. I also agree it take the FDA WAYYYY too long to get us meds we could use due to "red tape", however this is what worries me:
<br />
<br /><b>"The article in the May 2007 issue of The Lancet Infectious Diseases describes <u>a higher all-cause mortality in patients treated with cefepime compared to other ? - lactams</u>. Overall, the all-cause mortality was higher with cefepime than other ?-lactams (risk ratio [RR] 1·26 [95% CI 1·08 - 1·49]) and for the subgroup of patients with febrile neutropenia (RR 1·42 [95% CI 1·09 - 1·84])."</b>
<br />
<br />
<br />There obviously are unreasonably higher mortality rates that they think MAY be attributable to cefepime than other B-lactams (as the article states). I agree to read carefully and not draw unwarranted conclusions, which I have tried not to do, however, if you read the article in its entirety, you will see that this is different than just the usual "side effects" or "risks" involved with any drug.
<br />
<br />Either way, I know its important to discuss things like this with the docs and I do plan on doing so this friday at my appt. I am just very pro-active and like to know what I'm putting in my veins (as we all are) and if there are alternatives to something that may or may not cause death (and is under investigation by the FDA for said complications), I think I'd rather my docs choose those until more information can be obtained.
<br />
<br />I have argued in the past when my doctor wanted to put me on chloramphenicol and I did extensive online research that found that its use for CF should be a "last resort" as it has been shown to cause cancer, etc. more than other treatments for CF. Therefore, he did not prescribe it and found an alternative with "safer" consequences. I did very well on the med he used instead and felt a TON better about what I was putting into my body. I'm sure I would have worried the entire treatment had I read those studies and still used it when many other meds were still viable choices. That is all I'm referring to.
<br />
<br />I appreciate ya'll trying to put my mind at ease about this though. I know sometimes I need that! <img src="i/expressions/face-icon-small-wink.gif" border="0">
<br />
<br />

 

[ladybug]

Oophs! I don't think I ever actually linked to the FDA site that explains the reason for concern. Here it is:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/early_comm/cefepime.htm">http://www.fda.gov/cder/drug/early_comm/cefepime.htm</a>

This is where I got the previously quoted information. Sorry. The other one was just a medline site that had the warning at the top. My bad.

 

[ladybug]

Oophs! I don't think I ever actually linked to the FDA site that explains the reason for concern. Here it is:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/early_comm/cefepime.htm">http://www.fda.gov/cder/drug/early_comm/cefepime.htm</a>

This is where I got the previously quoted information. Sorry. The other one was just a medline site that had the warning at the top. My bad.

 

[ladybug]

Oophs! I don't think I ever actually linked to the FDA site that explains the reason for concern. Here it is:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/early_comm/cefepime.htm">http://www.fda.gov/cder/drug/early_comm/cefepime.htm</a>

This is where I got the previously quoted information. Sorry. The other one was just a medline site that had the warning at the top. My bad.

 

[ladybug]

Oophs! I don't think I ever actually linked to the FDA site that explains the reason for concern. Here it is:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/early_comm/cefepime.htm">http://www.fda.gov/cder/drug/early_comm/cefepime.htm</a>

This is where I got the previously quoted information. Sorry. The other one was just a medline site that had the warning at the top. My bad.

 

[ladybug]

Oophs! I don't think I ever actually linked to the FDA site that explains the reason for concern. Here it is:
<br />
<br /><a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/early_comm/cefepime.htm">http://www.fda.gov/cder/drug/early_comm/cefepime.htm</a>
<br />
<br />This is where I got the previously quoted information. Sorry. The other one was just a medline site that had the warning at the top. My bad.