<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>momtohazel</b></i>
we recently asked this question of a pediatirc GI doc who sees a lot of kiddos with CF. He did not cite the specific articles, but did say the research did not find that there was a one size fits all...some benefited most from taking at the beginning, some from taking them in the middle and some most from taking at the end of the meal. I suppose each GI system works in its own way and that is what accounts for the difference in timing.</end quote><br><br>This is why I've been taking it continuously while I eat for many years now. Start at first bite and continue popping enzymes, with last enzyme being popped right after last bite. This covers all aspects. If I'm with people who have no idea I take enzymes with my meals, I'll sometimes take half at the start and the rest at the end, sometimes with something in middle. Think I noticed feeling constipated when I had to do something like that though.<br><br>Just to add, be careful taking too many enzymes at one time. Too many within a certain time frame (my doc said the enzymes remain viable for about 20 min at a time) could yield the same results as if you hadn't taken any enzymes at all. This is why I wait about a half hour before I try to eat something more once my meal is done. Good luck to all!<br><br>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<br>Diagnosed at birth, CF, intermittent CFRD, hypothyroid<br>