i prefer PICC over IV, only because i hate being stuck...and the PICC line you really dont feel much getting it in; at least not for me, its just a little uncomfortable pressure (and i mean little, although every person is different) after they ultrasound for a good vein. and when u get it out...its like spreading butter on your bread, u dont even feel it. i remember i was sooooo scared of getting the line out on my first time, and i was like freaking out and almost in tears cuz i was afraid it was gonna hurt, and the nurse was like im gonna count to 3 and im gonna pull it out...and she counted, and i relaxed once it was "done" then she told me she had pulled it out 5 mins previous...i was so worked up over nothing!