mom2lillian
New member
Aminoglycoside-associated hypomagnesaemia in children with cystic fibrosis.
Akbar A,
Rees JH,
Nyamugunduru G,
English MW,
Spencer DA,
Weller PH.
Paediatric Respiratory and Cystic Fibrosis Unit, The Birmingham Children's Hospital NHS Trust, UK.
Hypomagnesaemia in children with cystic fibrosis (CF) is under-recognized. We report a child with CF who developed significant hypomagnesaemia following intravenous (i.v.) treatment with aminoglycosides (a class of antibiotics)exacerbations of Pseudomonas aeruginosa infection. Three additional cases have also been observed. Investigations in two patients have revealed excessive renal loss of magnesium. It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia (damage to the ears as a result of treatment with IV's has resulted in low magnesium -- or perhaps vice versa btu they are showing the link) , and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides. (Recommendation is that now when we get our peaks and troughs measured when on IV's we would aslo have them do a Magnesium check at this time)
Akbar A,
Rees JH,
Nyamugunduru G,
English MW,
Spencer DA,
Weller PH.
Paediatric Respiratory and Cystic Fibrosis Unit, The Birmingham Children's Hospital NHS Trust, UK.
Hypomagnesaemia in children with cystic fibrosis (CF) is under-recognized. We report a child with CF who developed significant hypomagnesaemia following intravenous (i.v.) treatment with aminoglycosides (a class of antibiotics)exacerbations of Pseudomonas aeruginosa infection. Three additional cases have also been observed. Investigations in two patients have revealed excessive renal loss of magnesium. It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia (damage to the ears as a result of treatment with IV's has resulted in low magnesium -- or perhaps vice versa btu they are showing the link) , and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides. (Recommendation is that now when we get our peaks and troughs measured when on IV's we would aslo have them do a Magnesium check at this time)