My wife and I are trying for a child

T

TerryR

New member
<P>My wife and I are about to try for a child. We have recently found out that my wife is a carrier for Cystic Fibrosis delta F508 mutation. I am a negative carrier for the common Cystic Fibrosis mutation but I have an interon 5T varient. Can anyone tell us or give us some idea on the possible outcome should we have a child together.</P>
<P>1. What is the likely hood of our future child being poorly at all as a percentage if possible ?</P>
<P>2. How severe is any effect likely to be on the childs health ?</P>
<P>£. Again as a percentage how many males are likely to carry a mutation or interon that would be likely to cause a complicatin when the other partner is a Carrier for Cystic Fibrosis delta F508 mutation.</P>
<P> </P>
<P>Please help if you can, we are booked in for a consultation, but we would appreciate any help/advice that may be available before hand.</P>
<P> </P>
<P>Many Thanks Terry</P>
 
T

TerryR

New member
<P>My wife and I are about to try for a child. We have recently found out that my wife is a carrier for Cystic Fibrosis delta F508 mutation. I am a negative carrier for the common Cystic Fibrosis mutation but I have an interon 5T varient. Can anyone tell us or give us some idea on the possible outcome should we have a child together.</P>
<P>1. What is the likely hood of our future child being poorly at all as a percentage if possible ?</P>
<P>2. How severe is any effect likely to be on the childs health ?</P>
<P>£. Again as a percentage how many males are likely to carry a mutation or interon that would be likely to cause a complicatin when the other partner is a Carrier for Cystic Fibrosis delta F508 mutation.</P>
<P></P>
<P>Please help if you can, we are booked in for a consultation, but we would appreciate any help/advice that may be available before hand.</P>
<P></P>
<P>Many Thanks Terry</P>
 
T

TerryR

New member
<P><BR>My wife and I are about to try for a child. We have recently found out that my wife is a carrier for Cystic Fibrosis delta F508 mutation. I am a negative carrier for the common Cystic Fibrosis mutation but I have an interon 5T varient. Can anyone tell us or give us some idea on the possible outcome should we have a child together.</P>
<P>1. What is the likely hood of our future child being poorly at all as a percentage if possible ?</P>
<P>2. How severe is any effect likely to be on the childs health ?</P>
<P>£. Again as a percentage how many males are likely to carry a mutation or interon that would be likely to cause a complicatin when the other partner is a Carrier for Cystic Fibrosis delta F508 mutation.</P>
<P></P>
<P>Please help if you can, we are booked in for a consultation, but we would appreciate any help/advice that may be available before hand.</P>
<P></P>
<P>Many Thanks Terry</P>
 
B

Bexterdesigns

New member
I agree with the other respondent-  talk to a genetic counselor.  My understanding is you don't need to have the same mutation as your spouse for your child to have CF, and basic high school genetics says a double recessive like CF means you have a 1 in 4 chance, but I am definitely not an expert.  My brother in law was a definite carrier, but we thought my sister was not, she tested negative.  When they had a child with CF they re-tested, and they found the mutation she had was only able to be tested for 2 years after she was screened.  Please talk to an expert, and good luck!
 
B

Bexterdesigns

New member
I agree with the other respondent- talk to a genetic counselor. My understanding is you don't need to have the same mutation as your spouse for your child to have CF, and basic high school genetics says a double recessive like CF means you have a 1 in 4 chance, but I am definitely not an expert. My brother in law was a definite carrier, but we thought my sister was not, she tested negative. When they had a child with CF they re-tested, and they found the mutation she had was only able to be tested for 2 years after she was screened. Please talk to an expert, and good luck!
 
B

Bexterdesigns

New member
I agree with the other respondent- talk to a genetic counselor. My understanding is you don't need to have the same mutation as your spouse for your child to have CF, and basic high school genetics says a double recessive like CF means you have a 1 in 4 chance, but I am definitely not an expert. My brother in law was a definite carrier, but we thought my sister was not, she tested negative. When they had a child with CF they re-tested, and they found the mutation she had was only able to be tested for 2 years after she was screened. Please talk to an expert, and good luck!
 
J

julie

New member
No, you do NOT need to have the same mutations for your child to end up with CF. http://www.cysticfibrosismaleinfertility.com/Where_to_begin.html You have a 25% change of having a child with CF.
 
J

julie

New member
No, you do NOT need to have the same mutations for your child to end up with CF. http://www.cysticfibrosismaleinfertility.com/Where_to_begin.html You have a 25% change of having a child with CF.
 
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