First on congrats on your pregnancy! Your going to love being a mommy =) Secondly to answer your question. Yes pulmozyme is safe. I used it through out my whole pregnancy. so is xopenix. Im not sure what other meds your on but those are the only ones I use and used through my pregnancy. Im on tobi month to month, however that I couldnt use. Hope that helped. Feel free to message me with any questions you might have. I know I had a million with my first child and now am thinking about trying for a second =)