Nightwriter, I'm not disputing what you cited, I am saying that the story you related from your doc is missing quite a bit of information and that it's far more likely that that patient died from the bronchospasm than from a beta-agonist OD. No matter how beta specific a drug like albuterol or xopenex claims to be there's still some stimulation of alpha receptors in the heart and therefore all those drugs can increase heart rate and cardiac contractility etc. The old ones like alupent were really bad. Once when I was little I accidentally OD'd myself on alupent and tached out to like 170BPM. Anyway, if you look through the PDR or peruse Rxlist.com and read all the adverse effects of any drug you can frighten yourself out of taking just about anything. They have to list every clinically significant adverse effect that were observed during the trials, but that doesn't mean that everyone is at risk of developing those adverse effects and it also doesn't lock you into the usual doses (obviously with the blessing of your doc).
The truth is YOU and your doc need to figure out what is right for you. Since it's your body, you are going to have far more insight on what works for you and how much of it you can tolerate than your physician will. You should also educate yourself to the point that you can work with your doc almost like a colleague. When I call my CF center, I give them a rundown of my symptoms, onset and duration and then what I would like to do about it. Most of the time they go along with my plan, if my doc wants to try something else he will call me and we will discuss it together.
To clarify, I am not a pulmonologist, rather I'm a paramedic. Which in my opinion is perhaps more challenging in that we have to be proficient in treating patients who present with a multitude of medical problems or traumatic injuries and do it very quickly in an uncontrolled environment. And yes, I have treated quite a few advanced asthma cases, the most recent a 17yo who treated himself with albuterol 2.5mg nebs and waited nearly 12 hours to call 911. By the time I got him he'd done 5mg on his own, I gave him an additional 5mg, 0.5mg of 1:1000 Epi, and 125mg methylprednisolone. He dropped his respiratory drive and we put him on bipap, until he became unresponsive which is a contraindication to the use of bipap and we had to assist his ventilations with a bag valve mask. Had I been any further from the hospital I would have ended up intubating him. In this case had he not called 911 or waited much longer he'd be dead, but from the bronchospasm and not the successive albuterol nebs.
It is disheartening to me when I encounter a patient who goes to their doc and blindly takes whatever pills they throw at them without understanding why. Most people are not taking an active role in their own health and well being and frankly, we all should be. I think we in the CF community are particularly well educated about our disease. Since prevention and maintenance are key, we should be very, very involved in the development of our treatment plan.