I don't know what your lungs are like now but depending on the percentage of the HTS, it will more than likely make you cough a lot until you get used to it. I hated that stuff.
As for the colistin, I think that it kind of has a weird taste like TOBI does but it's not as bad. I also had some trouble with the colistin foaming out and coming out of the neb. Sometimes the foam would get up into the mouth piece and that was horrible. I only ever did colistin in the hospital, so the foaming may have had something to do with the way they mixed it.
Good luck on your new meds.