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Sweat Test Required?
- Thread starter 3andahalf
- Start date
A single (D F508) mutation would only prove that the child is a CF carrier. A sweat test would go a long way in determining if the child has CF.
I would be interested in how many mutations your child was screened for when they found the D F508. There are almost 1900 know mutations, any one, along with the D F508, would prove that the child has CF.
Basically, at this point, you know very little and YES a sweat test needs to be done.
Bill
I would be interested in how many mutations your child was screened for when they found the D F508. There are almost 1900 know mutations, any one, along with the D F508, would prove that the child has CF.
Basically, at this point, you know very little and YES a sweat test needs to be done.
Bill
A single (D F508) mutation would only prove that the child is a CF carrier. A sweat test would go a long way in determining if the child has CF.
I would be interested in how many mutations your child was screened for when they found the D F508. There are almost 1900 know mutations, any one, along with the D F508, would prove that the child has CF.
Basically, at this point, you know very little and YES a sweat test needs to be done.
Bill
I would be interested in how many mutations your child was screened for when they found the D F508. There are almost 1900 know mutations, any one, along with the D F508, would prove that the child has CF.
Basically, at this point, you know very little and YES a sweat test needs to be done.
Bill
A single (D F508) mutation would only prove that the child is a CF carrier. A sweat test would go a long way in determining if the child has CF.
I would be interested in how many mutations your child was screened for when they found the D F508. There are almost 1900 know mutations, any one, along with the D F508, would prove that the child has CF.
Basically, at this point, you know very little and YES a sweat test needs to be done.
Bill
I would be interested in how many mutations your child was screened for when they found the D F508. There are almost 1900 know mutations, any one, along with the D F508, would prove that the child has CF.
Basically, at this point, you know very little and YES a sweat test needs to be done.
Bill
<P>Thank you foryour comments! Wantedto let you know (in case there was interest) I spoke with the CF Foundation and my local genetics center. The CF Foundationlady said no, she didn't need a sweat test b/c the chance of their being another mutation was so small, and if there was either my husband or I would be a carrier, and thus effected with the disease, which we are not..</P>
<P></P>
<P>The local genetics center saidyes, she does need the sweat test, at first, until they learned she had a known mutation and said if she was heterozygous for DeltaF508 she would be showing symptoms. When I mentioned thelesser known mutations you all pointed out, she said the same as the CF Foundation but that if our doctor and us wanted a sweat test to put our minds at ease it would bewarranted.</P>
<P></P>
<P>The only odd thing I've ever noticed is salt crusts onmy daughterspillow case, big round circles of white, but only in the summer when she's hot. She doesn't have any classic CF symptoms..if anything myson would be more worrying he has chronic sinuscongestion, cough, bowel issues like constipation and smelly gas and peebut they say he has allergic asthma andthe cough/congestion is controlled well with allergy/asthmamedicine. His sweat test (he is also DeltaF508 carrier) came backnegative 3 years ago.</P>
<P></P>
<P>What would you do? </P>
<P></P>
<P>The local genetics center saidyes, she does need the sweat test, at first, until they learned she had a known mutation and said if she was heterozygous for DeltaF508 she would be showing symptoms. When I mentioned thelesser known mutations you all pointed out, she said the same as the CF Foundation but that if our doctor and us wanted a sweat test to put our minds at ease it would bewarranted.</P>
<P></P>
<P>The only odd thing I've ever noticed is salt crusts onmy daughterspillow case, big round circles of white, but only in the summer when she's hot. She doesn't have any classic CF symptoms..if anything myson would be more worrying he has chronic sinuscongestion, cough, bowel issues like constipation and smelly gas and peebut they say he has allergic asthma andthe cough/congestion is controlled well with allergy/asthmamedicine. His sweat test (he is also DeltaF508 carrier) came backnegative 3 years ago.</P>
<P></P>
<P>What would you do? </P>
<P>Thank you foryour comments! Wantedto let you know (in case there was interest) I spoke with the CF Foundation and my local genetics center. The CF Foundationlady said no, she didn't need a sweat test b/c the chance of their being another mutation was so small, and if there was either my husband or I would be a carrier, and thus effected with the disease, which we are not..</P>
<P></P>
<P>The local genetics center saidyes, she does need the sweat test, at first, until they learned she had a known mutation and said if she was heterozygous for DeltaF508 she would be showing symptoms. When I mentioned thelesser known mutations you all pointed out, she said the same as the CF Foundation but that if our doctor and us wanted a sweat test to put our minds at ease it would bewarranted.</P>
<P></P>
<P>The only odd thing I've ever noticed is salt crusts onmy daughterspillow case, big round circles of white, but only in the summer when she's hot. She doesn't have any classic CF symptoms..if anything myson would be more worrying he has chronic sinuscongestion, cough, bowel issues like constipation and smelly gas and peebut they say he has allergic asthma andthe cough/congestion is controlled well with allergy/asthmamedicine. His sweat test (he is also DeltaF508 carrier) came backnegative 3 years ago.</P>
<P></P>
<P>What would you do? </P>
<P></P>
<P>The local genetics center saidyes, she does need the sweat test, at first, until they learned she had a known mutation and said if she was heterozygous for DeltaF508 she would be showing symptoms. When I mentioned thelesser known mutations you all pointed out, she said the same as the CF Foundation but that if our doctor and us wanted a sweat test to put our minds at ease it would bewarranted.</P>
<P></P>
<P>The only odd thing I've ever noticed is salt crusts onmy daughterspillow case, big round circles of white, but only in the summer when she's hot. She doesn't have any classic CF symptoms..if anything myson would be more worrying he has chronic sinuscongestion, cough, bowel issues like constipation and smelly gas and peebut they say he has allergic asthma andthe cough/congestion is controlled well with allergy/asthmamedicine. His sweat test (he is also DeltaF508 carrier) came backnegative 3 years ago.</P>
<P></P>
<P>What would you do? </P>
<P>Thank you foryour comments! Wantedto let you know (in case there was interest) I spoke with the CF Foundation and my local genetics center. The CF Foundationlady said no, she didn't need a sweat test b/c the chance of their being another mutation was so small, and if there was either my husband or I would be a carrier, and thus effected with the disease, which we are not..</P>
<P></P>
<P>The local genetics center saidyes, she does need the sweat test, at first, until they learned she had a known mutation and said if she was heterozygous for DeltaF508 she would be showing symptoms. When I mentioned thelesser known mutations you all pointed out, she said the same as the CF Foundation but that if our doctor and us wanted a sweat test to put our minds at ease it would bewarranted.</P>
<P></P>
<P>The only odd thing I've ever noticed is salt crusts onmy daughterspillow case, big round circles of white, but only in the summer when she's hot. She doesn't have any classic CF symptoms..if anything myson would be more worrying he has chronic sinuscongestion, cough, bowel issues like constipation and smelly gas and peebut they say he has allergic asthma andthe cough/congestion is controlled well with allergy/asthmamedicine. His sweat test (he is also DeltaF508 carrier) came backnegative 3 years ago.</P>
<P></P>
<P>What would you do? </P>
<P></P>
<P>The local genetics center saidyes, she does need the sweat test, at first, until they learned she had a known mutation and said if she was heterozygous for DeltaF508 she would be showing symptoms. When I mentioned thelesser known mutations you all pointed out, she said the same as the CF Foundation but that if our doctor and us wanted a sweat test to put our minds at ease it would bewarranted.</P>
<P></P>
<P>The only odd thing I've ever noticed is salt crusts onmy daughterspillow case, big round circles of white, but only in the summer when she's hot. She doesn't have any classic CF symptoms..if anything myson would be more worrying he has chronic sinuscongestion, cough, bowel issues like constipation and smelly gas and peebut they say he has allergic asthma andthe cough/congestion is controlled well with allergy/asthmamedicine. His sweat test (he is also DeltaF508 carrier) came backnegative 3 years ago.</P>
<P></P>
<P>What would you do? </P>
meteoras69
New member
<br>If you know that your child has two DF508 mutations, then there is no need for a sweat test; your child has CF. I was not clear from your original post if you knew that your child had only one mutation or two. If your has only one mutation that you know of, then further testing is needed. I would urge you to get complete genetics testing for all known mutations if you already know that your child has DF508. Sweat tests can turn up negative even when children do have CF; there are many rare mutations and it never hurts to be sure.......Best wishes in your search for answers.
meteoras69
New member
<br>If you know that your child has two DF508 mutations, then there is no need for a sweat test; your child has CF. I was not clear from your original post if you knew that your child had only one mutation or two. If your has only one mutation that you know of, then further testing is needed. I would urge you to get complete genetics testing for all known mutations if you already know that your child has DF508. Sweat tests can turn up negative even when children do have CF; there are many rare mutations and it never hurts to be sure.......Best wishes in your search for answers.