<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>cdale613</b></i> Hi All, I have been on Kalydeco for two weeks through the last VX-770 research effort tracking long term use for a year at UVA. I am continuing my full routine of meds for the time being. The first change I notices were my nasal passages - within about 4 hours. They feel like I just did a sinus rinse. Chest wise, I noticed a difference in 3 days. I feel MUCH less tight or inflamed. I don't hear crackles when I lie down to go to sleep, etc. It basically feels like I'm in the middle of a course of IVs without the nasty side effects... My level of congestion/mucous production has lessened some, but I continue to be quite productive. However, my color has been all over the place - some days very light greenish yellow, other days gross greenish brown. I have been getting up a few plugs, though nothing black, etc. After five days, my FEV1 was up 4%, to 84% of normal. The biggest noticeable change so far has been in my digestive tract - My bowels feel great, using the bathroom less frequently, and everything is sinking... I've also gained a couple pounds, but have been changing my diet to not gain weight. My BMI is 22, and I am happy with it where it is, and have no desire to gain. Emotionally it has been quite a roller coaster - I feel like I have been told I will live, and it is incredible. A huge weight feels like it is lifting off of me. I am aware of how incredibly lucky I am, and its a lot to take in. I feel like I have flipped a hundred coins, and every one has come up heads. My wife and I talked about kids for the first time in four years of marriage last week. Its amazing to see her belief that something like this would happen be validated. I also feel guilty to be among the so few benefiting from this. However, I also feel like I worked incredibly hard to put myself in a position to benefit from a drug like this at age 31, and I have to pinch myself - I can't believe it is here. If I had anything to say to everyone not immediately impacted by Kalydeco, it is this: Keep doing the hard work. It isn't easy, but its worth it, and it will pay off for all of us. Chris</end quote>
<span style="font-size: small; font-family: 'comic sans ms', sans-serif;">Chris~
<span style="font-size: small; font-family: 'comic sans ms', sans-serif;">This is AWESOME!!!!! I am so excited for you and your family. You did hit the CF lotto. I think you are so wise to encourage all of us to work hard and take care of ourselves. I never thought I would see this day!! Praise GOD!
<span style="font-size: small; font-family: 'comic sans ms', sans-serif;">I am VERY intrigued by what you are saying as far as the nasal passages the first day. I know someone who felt the EXACT same way. Like moisture, I think.
<span style="font-size: small; font-family: 'comic sans ms', sans-serif;">Question for you. Before the Kalydeco, were you a productive cougher or more tight and/or inflamed?
<span style="font-size: small; font-family: 'comic sans ms', sans-serif;">So, so happy for you. Thank you for sharing with us what it is like.
<span style="font-size: small; font-family: 'comic sans ms', sans-serif;">Mandy
