I have drank mucomyst when I had blockage some yrs back. My blockage was caused some what because I was not hydrated enough. Have had to cut back on my Creon. It seems to me, I do not needed as much Creon. I am suppose to take 3, 24k Creon, but I take 2 with each meal. The Creon has more lipase than the Ultrase. I also drink a lot more water than I use too. Beware of meat, steak, chicken, shrimp, roast; if you do not chew well and drink plenty of fluids, it can cause problems with blockage. I also had colon resection for colon Ca 9+ yrs. ago. Ever since I had the resection, have had to watch how and what I eat. never had problems or blockage before surg. I think where they sew the colon back together is part of the problem, too small of a opening, maybe because of scar tissue? Mucomyst is on back order by manf.have not been able to get it for some months now, I neb it 2-3 times a day. Good luck!!