I flew Delta earlier this year & I had no problems. I had a letter from the doctor outlining Max's diagnosis & made sure the RX labels were on the medication. In addition, the medical equipment (which included his vest & another bag w/his meds & vest accessories) did not count toward my carry-on allowance. I was hesitant to check anything related to his care for fear of damage or loss. I also used one of the "pulmozyme" ice packs to keep it chilled & it worked wonderfully. It would probably be a good idea to check your airlines website to see if they have any specific suggestions about what they need to make it a smooth process. Hope that you have a great trip without any hassles!