Zyvox (along with Ketek in combination with Bactrim DS) are the only oral abx's that work for me now. My doctor will prescribe Zyvox for 2 weeks usually and then Ketek for 2 weeks, followed by Zyvox again, Ketek again, and then hospital time. Usually by the 4th time of orals, Ketek doesn't work. It does keep the staph down very well though. I actually didn't culture it this time after being on it for a week.
Zyvox used to work much better than it does now, but it still keeps me out of the hospital. I dread the time that it stops working..luckily the combination of Vancomycin, Tobra, and Fortaz in the hospital still gets me pretty healthy. I hardly ever use Zyvox IV though.