Denufosol Trial

[dramamama]

Actually, it opens a different channel than the cftr channel which is either defective or missing in cf. This drug actually causes the cells in the lungs to efflux fluid like a normal lung.....It dosen't correct the cftr channel....however, it opens another one that appears to do the same thing.

It is not just like hypertonic saline Amy. It does hydrate the lung in a much different way. The salt from hypertonic saline pulls water from the cell and allows secretions some moisture and the cilia to beat. This actually CREATES a new channel thereby changing the mechanism by which the lung hydrates itself.

It is TOTALLY different and much more effective.

Here is a direct quote from recent literature:
<b> Denufosol tetrasodium is a selective P2Y2 agonist designed to enhance the lung's innate mucosal hydration and mucociliary clearance mechanisms by activating an alternative ion channel that acts in the same way as the defective ion channel normally would in moving salt and water to the surface of the airways.


This is a critical development for CF patients and could represent an entirely new way to correct the basic defect in cells that line the airways, said Robert J. Beall, Ph.D., president and CEO of the Cystic Fibrosis Foundation</b>.

 

[dramamama]

Actually, it opens a different channel than the cftr channel which is either defective or missing in cf. This drug actually causes the cells in the lungs to efflux fluid like a normal lung.....It dosen't correct the cftr channel....however, it opens another one that appears to do the same thing.

It is not just like hypertonic saline Amy. It does hydrate the lung in a much different way. The salt from hypertonic saline pulls water from the cell and allows secretions some moisture and the cilia to beat. This actually CREATES a new channel thereby changing the mechanism by which the lung hydrates itself.

It is TOTALLY different and much more effective.

Here is a direct quote from recent literature:
<b> Denufosol tetrasodium is a selective P2Y2 agonist designed to enhance the lung's innate mucosal hydration and mucociliary clearance mechanisms by activating an alternative ion channel that acts in the same way as the defective ion channel normally would in moving salt and water to the surface of the airways.


This is a critical development for CF patients and could represent an entirely new way to correct the basic defect in cells that line the airways, said Robert J. Beall, Ph.D., president and CEO of the Cystic Fibrosis Foundation</b>.

 

[dramamama]

Actually, it opens a different channel than the cftr channel which is either defective or missing in cf. This drug actually causes the cells in the lungs to efflux fluid like a normal lung.....It dosen't correct the cftr channel....however, it opens another one that appears to do the same thing.

It is not just like hypertonic saline Amy. It does hydrate the lung in a much different way. The salt from hypertonic saline pulls water from the cell and allows secretions some moisture and the cilia to beat. This actually CREATES a new channel thereby changing the mechanism by which the lung hydrates itself.

It is TOTALLY different and much more effective.

Here is a direct quote from recent literature:
<b> Denufosol tetrasodium is a selective P2Y2 agonist designed to enhance the lung's innate mucosal hydration and mucociliary clearance mechanisms by activating an alternative ion channel that acts in the same way as the defective ion channel normally would in moving salt and water to the surface of the airways.


This is a critical development for CF patients and could represent an entirely new way to correct the basic defect in cells that line the airways, said Robert J. Beall, Ph.D., president and CEO of the Cystic Fibrosis Foundation</b>.

 

[dramamama]

Actually, it opens a different channel than the cftr channel which is either defective or missing in cf. This drug actually causes the cells in the lungs to efflux fluid like a normal lung.....It dosen't correct the cftr channel....however, it opens another one that appears to do the same thing.

It is not just like hypertonic saline Amy. It does hydrate the lung in a much different way. The salt from hypertonic saline pulls water from the cell and allows secretions some moisture and the cilia to beat. This actually CREATES a new channel thereby changing the mechanism by which the lung hydrates itself.

It is TOTALLY different and much more effective.

Here is a direct quote from recent literature:
<b> Denufosol tetrasodium is a selective P2Y2 agonist designed to enhance the lung's innate mucosal hydration and mucociliary clearance mechanisms by activating an alternative ion channel that acts in the same way as the defective ion channel normally would in moving salt and water to the surface of the airways.


This is a critical development for CF patients and could represent an entirely new way to correct the basic defect in cells that line the airways, said Robert J. Beall, Ph.D., president and CEO of the Cystic Fibrosis Foundation</b>.

 

[eli]

Thanks Amy, i will check it out tomorrow. Its time for bed now<img src="i/expressions/moon.gif" border="0">

Although, it does sound like realy cool new med. I hope it does well in the trials and is aout on the market asap.

But what i can't understand is, why do they keep making and/or trialing drugs that work the same way as others. Why not try and invent a totaly new thing, somthing that attacks other areas, if you get my drift.<img src="i/expressions/face-icon-small-confused.gif" border="0">

 

[eli]

Thanks Amy, i will check it out tomorrow. Its time for bed now<img src="i/expressions/moon.gif" border="0">

Although, it does sound like realy cool new med. I hope it does well in the trials and is aout on the market asap.

But what i can't understand is, why do they keep making and/or trialing drugs that work the same way as others. Why not try and invent a totaly new thing, somthing that attacks other areas, if you get my drift.<img src="i/expressions/face-icon-small-confused.gif" border="0">

 

[eli]

Thanks Amy, i will check it out tomorrow. Its time for bed now<img src="i/expressions/moon.gif" border="0">

Although, it does sound like realy cool new med. I hope it does well in the trials and is aout on the market asap.

But what i can't understand is, why do they keep making and/or trialing drugs that work the same way as others. Why not try and invent a totaly new thing, somthing that attacks other areas, if you get my drift.<img src="i/expressions/face-icon-small-confused.gif" border="0">

 

[eli]

Thanks Amy, i will check it out tomorrow. Its time for bed now<img src="i/expressions/moon.gif" border="0">

Although, it does sound like realy cool new med. I hope it does well in the trials and is aout on the market asap.

But what i can't understand is, why do they keep making and/or trialing drugs that work the same way as others. Why not try and invent a totaly new thing, somthing that attacks other areas, if you get my drift.<img src="i/expressions/face-icon-small-confused.gif" border="0">

 

[eli]

Thanks Amy, i will check it out tomorrow. Its time for bed now<img src="i/expressions/moon.gif" border="0">

Although, it does sound like realy cool new med. I hope it does well in the trials and is aout on the market asap.

But what i can't understand is, why do they keep making and/or trialing drugs that work the same way as others. Why not try and invent a totaly new thing, somthing that attacks other areas, if you get my drift.<img src="i/expressions/face-icon-small-confused.gif" border="0">

 

[eli]

Thanks Amy, i will check it out tomorrow. Its time for bed now<img src="i/expressions/moon.gif" border="0">

Although, it does sound like realy cool new med. I hope it does well in the trials and is aout on the market asap.

But what i can't understand is, why do they keep making and/or trialing drugs that work the same way as others. Why not try and invent a totaly new thing, somthing that attacks other areas, if you get my drift.<img src="i/expressions/face-icon-small-confused.gif" border="0">

 

[eli]

WOW Mandy, i just read your edited version. It sounds awesome, i real realy realy hope it goes to plan and gets approved.

OMG, this drug will be like a new lease on life for every cf'er. I am so hopefull and pray that it makes ith through with flying colours.

Please keep me posted on this topic, pm me when ever you like. I realy am interested.

Thanks again for sharing<img src="i/expressions/face-icon-small-happy.gif" border="0">

 

[eli]

WOW Mandy, i just read your edited version. It sounds awesome, i real realy realy hope it goes to plan and gets approved.

OMG, this drug will be like a new lease on life for every cf'er. I am so hopefull and pray that it makes ith through with flying colours.

Please keep me posted on this topic, pm me when ever you like. I realy am interested.

Thanks again for sharing<img src="i/expressions/face-icon-small-happy.gif" border="0">

 

[eli]

WOW Mandy, i just read your edited version. It sounds awesome, i real realy realy hope it goes to plan and gets approved.

OMG, this drug will be like a new lease on life for every cf'er. I am so hopefull and pray that it makes ith through with flying colours.

Please keep me posted on this topic, pm me when ever you like. I realy am interested.

Thanks again for sharing<img src="i/expressions/face-icon-small-happy.gif" border="0">

 

[eli]

WOW Mandy, i just read your edited version. It sounds awesome, i real realy realy hope it goes to plan and gets approved.

OMG, this drug will be like a new lease on life for every cf'er. I am so hopefull and pray that it makes ith through with flying colours.

Please keep me posted on this topic, pm me when ever you like. I realy am interested.

Thanks again for sharing<img src="i/expressions/face-icon-small-happy.gif" border="0">

 

[eli]

WOW Mandy, i just read your edited version. It sounds awesome, i real realy realy hope it goes to plan and gets approved.

OMG, this drug will be like a new lease on life for every cf'er. I am so hopefull and pray that it makes ith through with flying colours.

Please keep me posted on this topic, pm me when ever you like. I realy am interested.

Thanks again for sharing<img src="i/expressions/face-icon-small-happy.gif" border="0">

 

[eli]

WOW Mandy, i just read your edited version. It sounds awesome, i real realy realy hope it goes to plan and gets approved.

OMG, this drug will be like a new lease on life for every cf'er. I am so hopefull and pray that it makes ith through with flying colours.

Please keep me posted on this topic, pm me when ever you like. I realy am interested.

Thanks again for sharing<img src="i/expressions/face-icon-small-happy.gif" border="0">

 

[NoExcuses]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>dramamama</b></i>

in moving salt and water to the surface of the airways.
</b>.</end quote></div>


I never said that the efficacy was the same.

I said that the workings were similar. Which they are - if you re-read what i said, and what you described, the end result is the same - moving salt and water to the surface of he airways.

But I appreciate your more thorough explanation <img src="i/expressions/face-icon-small-smile.gif" border="0">

 

[NoExcuses]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>dramamama</b></i>

in moving salt and water to the surface of the airways.
</b>.</end quote></div>


I never said that the efficacy was the same.

I said that the workings were similar. Which they are - if you re-read what i said, and what you described, the end result is the same - moving salt and water to the surface of he airways.

But I appreciate your more thorough explanation <img src="i/expressions/face-icon-small-smile.gif" border="0">

 

[NoExcuses]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>dramamama</b></i>

in moving salt and water to the surface of the airways.
</b>.</end quote></div>


I never said that the efficacy was the same.

I said that the workings were similar. Which they are - if you re-read what i said, and what you described, the end result is the same - moving salt and water to the surface of he airways.

But I appreciate your more thorough explanation <img src="i/expressions/face-icon-small-smile.gif" border="0">

 

[NoExcuses]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>dramamama</b></i>

in moving salt and water to the surface of the airways.
</b>.</end quote></div>


I never said that the efficacy was the same.

I said that the workings were similar. Which they are - if you re-read what i said, and what you described, the end result is the same - moving salt and water to the surface of he airways.

But I appreciate your more thorough explanation <img src="i/expressions/face-icon-small-smile.gif" border="0">