<p style="font-size: 12px; border-style: initial; border-color: initial; background-color: rgb(250, 250, 250); ">Pulmozyme=5-10 minutes<p style="font-size: 12px; border-style: initial; border-color: initial; background-color: rgb(250, 250, 250); ">Albuterol=5-10 minutes<p style="font-size: 12px; border-style: initial; border-color: initial; background-color: rgb(250, 250, 250); ">TOBI=FOREVER<p style="font-size: 12px; border-style: initial; border-color: initial; background-color: rgb(250, 250, 250); ">Hypertonic=10 minutes<p style="font-size: 12px; border-style: initial; border-color: initial; background-color: rgb(250, 250, 250); "><br><p style="font-size: 12px; border-style: initial; border-color: initial; background-color: rgb(250, 250, 250); ">I have two nebulizers, one at my house one at my boyfriend's. One is newer/faster. They still take about the same time regardless, in my experience. I can definitely use the vest for twenty and get pulmozyme and albuterol both in, and sometimes even hypertonic saline. I am a deep breather though, maybe its different if you breathe more shallowly/less often.