We just got back from Disneyworld 3 days ago. I have 3 kids 6,4,2 and my 2 year old has CF. She is on oxygen. We had no issues traveling with it or the vest or our multitude of medicines and nebulizer. They have a great Children's hospital in Orlando that is used to dealing with CF issues, I checked it out before we left, since every other time we have gone anywhere my daughter has ended up in the hospital. We had no issues. The weather was amazing. The two things that we did to ease my worries about the kids getting lost was writing my cell phone # on thier arms with a sharpie and taking a picture of them each morning before we left the hotel so if they did get lost we would remember exactly what they were wearing. We did not need either thing. The crowds were not bad at all except for on Saturday. This is the perfect time of year to go.